Defining Population at Risk and Assessment of Patients With Presumed Coronary Microvascular and Vasomotor Dysfunction

Area of Science:

• Cardiology
• Vascular Biology
• Clinical Research

Background:

• Coronary microvascular and vasomotor dysfunction significantly impact patient prognosis but lack targeted therapies.
• Patient population heterogeneity and complex pathophysiology hinder treatment development.
• Existing diagnostic and therapeutic strategies are limited.

Purpose of the Study:

• To identify at-risk patient groups and clinical conditions associated with coronary microvascular and vasomotor dysfunction.
• To define non-invasive tests for assessing peripheral and coronary vascular function.
• To establish metrics for disease burden and outcome measurement for future clinical trials.

Main Methods:

• Review of clinical conditions and patient groups at risk.
• Identification of non-invasive tests for vascular function assessment.
• Definition of disease burden metrics for invasive assessment and outcome measures.

Main Results:

• Established criteria for identifying patients at risk.
• Selected non-invasive tests for baseline and follow-up assessments.
• Defined metrics for disease burden and outcome measures.

Conclusions:

• The Canadian Coronary Physiology Registry will incorporate defined variables for baseline and follow-up.
• Standardized invasive coronary function testing will be integrated with registry data.
• This framework will facilitate the design and execution of future clinical outcomes trials in Canada.