Related Experiment Video
Updated: Jan 31, 2026
05:26
Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications
Published on: April 13, 2022
4.0K
Engineering chitosan-functionalized liposomes for targeted drug delivery and biomedical applications
1Department of Otorhinolaryngology, The First Hospital of China Medical University, Shenyang, Liaoning, 110001, China.
International Journal of Biological Macromolecules
|January 29, 2026
Summary
Chitosan-functionalized liposomes combine the benefits of liposomes and chitosan for improved drug delivery. This hybrid system enhances stability, targeting, and controlled release for various biomedical applications.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Drug Delivery Systems
Background:
- Chitosan (CS) is a biocompatible polysaccharide with versatile properties for drug delivery.
- Liposomes are effective nanocarriers but face challenges like instability and premature drug leakage.
- Hybridization of liposomes with CS offers a strategy to overcome these limitations.
Purpose of the Study:
- To systematically review the design, fabrication, and characteristics of chitosan-functionalized liposomes.
- To analyze the impact of CS coating on liposome stability, drug loading, release, and biological interactions.
- To examine the applications of these hybrid systems across various administration routes and diseases.
Main Methods:
- Review of literature on chitosan nanoparticles and liposome preparation.
- Analysis of physicochemical properties of CS-functionalized liposomes.
- Evaluation of in vitro and in vivo performance data from various studies.
Main Results:
- CS coating significantly enhances liposomal colloidal stability and mucoadhesion.
- Improved drug loading efficiency and controlled/stimuli-responsive release kinetics were observed.
- Enhanced cellular uptake and therapeutic efficacy in cancer, infection, and inflammation models.
Conclusions:
- Chitosan-functionalized liposomes offer a multifunctional platform addressing limitations of individual components.
- These hybrid nanocarriers show promise for next-generation nanomedicines and advanced biomedical applications.
- The tunable nature of CS allows for further functionalization, expanding therapeutic potential.
Related Concept Videos
01:16Drug Delivery: Overview
844
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
844
01:18Drug Delivery: Enteral Route
1.7K
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
1.7K
01:29Drug Delivery: Parenteral Route
1.7K
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
1.7K
01:26Targets for Drug Action: Overview
10.2K
Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
10.2K
01:22Drug Delivery: Miscellaneous Routes
814
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
814
01:27Applications of Integration to Probability Density Functions
54
Continuous probability distributions are used to model random variables that can take on any real value within a specified range. These variables do not take on isolated or countable values but rather exist on a continuum. For example, the height of an individual can be measured with increasing precision—such as 163.5 or 165.25 centimeters—demonstrating that height is a continuous random variable.The behavior of such variables is described using a probability density function (PDF),...
54