Related Experiment Video
Updated: Jan 31, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Bridging the knowledge gap: Med Wise Rx helps older adults navigate comprehensive medication reviews
Background:
Older adults are at particular risk of medication-related problems, and thus, the Centers for Medicare & Medicaid Services reimburses providers to offer comprehensive medication reviews (CMRs) for Medicare Part D enrollees. Unfortunately, the CMR service is underutilized. The Med Wise Rx educational program was designed to help older adults increase their knowledge, skills, and self-efficacy to communicate with pharmacists and seek CMR services.
Objective:
To examine the effectiveness of the training by assessing older adults' understanding of a CMR and its potential benefits.
Methods:
This study is part of a clinical, waitlist control trial where participants received 2 virtual 90-minute sessions addressing why older adults are at increased medication safety risk, skills to communicate their concerns, and how to ask for a CMR. The program and home practice tools presented question about medicines, problem-solving scenarios, and video-modeling communication strategies. Participants' understanding of CMRs with an open-ended survey question at baseline, and postintervention at 8 weeks, and 6 months was analyzed using deductive content analysis. Responses were coded using a modified Donabedian model with 3 components: content, process, and outcomes.
Results:
Interviews from 67 respondents were analyzed at 3 timepoints. At baseline, only 21% of participants could explain the meaning of a CMR. Eight weeks after the training, 86% were able to explain the components of a CMR, and this understanding increased even further to 93% at 6 months. Participants' descriptions of CMRs included explaining how a CMR is done, what it involves, and the benefits of a CMR service. These understandings and knowledge were sustained at 6 months.
Conclusion:
Med Wise Rx effectively increased older adults' ability to explain CMR and its benefits. Future analyses will identify whether participants received a CMR service and explore associations between their understanding of a CMR and service participation.
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