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Transthoracic Echocardiography to Assess Post-Resuscitation Left Ventricular Dysfunction After Acute Myocardial Infarction and Cardiac Arrest in Pigs
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Symptom burden and secondary prevention in patients with left ventricular systolic dysfunction after acute myocardial

Eleonora Hamilton1, Tomas Jernberg2, Joakim Alfredsson3

  • 1Department of Clinical Sciences, Karolinska Institutet Institutionen för kliniska vetenskaper Danderyds sjukhus, Stockholm, Sweden eleonora.hamilton@ki.se.

Open Heart
|January 29, 2026
PubMed

Insights

Patients with reduced ejection fraction (EF) after myocardial infarction (MI) experience more symptoms and poorer secondary prevention. This highlights a critical need for improved post-MI care for heart failure patients.

Area of Science:

  • Cardiology
  • Public Health
  • Clinical Research

Background:

  • Lack of current data on left ventricular (LV) systolic dysfunction post myocardial infarction (MI).
  • Focus on symptom burden and secondary prevention measures in these patients.
  • Need for contemporary data on LV dysfunction post-MI.

Purpose of the Study:

  • Describe patients with varying degrees of LV systolic dysfunction after a first MI.
  • Assess symptom burden, quality of life, and adherence to secondary prevention.
  • Utilize nationwide patient data for comprehensive analysis.

Main Methods:

  • Analysis of 49,564 patients from the Swedish Web-System for Enhancement and Development of Evidence-Based Care in Heart Disease registry (2011-2018).
  • Inclusion criteria: first acute MI, discharged alive, no prior heart failure.
  • Stratification based on the degree of LV systolic dysfunction.

Main Results:

  • Patients with EF <30% reported significantly more shortness of breath (32.3% vs 5.6%) and higher readmission rates (48.1% vs 31.2%) compared to normal EF.
  • Reduced EF patients were more often on sick leave (26.6% vs 9.5%).
  • No significant differences in chest pain or quality of life were observed; lower participation in education and physical therapy noted for EF <30%.

Conclusions:

  • LV systolic dysfunction post-MI is linked to substantial symptom burden.
  • Worse secondary prevention adherence observed in patients with reduced EF.
  • Contemporary data underscore the need for enhanced post-MI care strategies.
Abstract

Keywords:
Acute Coronary SyndromeCoronary Artery DiseaseEpidemiologyHEART FAILURERisk Factors

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