Related Experiment Video
Updated: Jan 31, 2026
04:39
Isolation of Primary Mouse Retinal Glial Müller Cells
Published on: August 30, 2024
2.9K
Future Directions in Müller-Weiss Disease Whither the Way Forward?
Michael M Stephens1, John Wong-Chung2
1Department of Foot & Ankle Surgery, St. Raphael's House, 81/84 Upper Dorset Street, Dublin D01 KX02, Ireland.
Foot and Ankle Clinics
|January 29, 2026
Summary
Müller-Weiss disease awareness is crucial for radiologists. Standardized reporting using Wong groups and Maceira stages is recommended for better outcomes in this rare navicular bone condition.
Area of Science:
- Orthopedics
- Radiology
- Podiatry
Background:
- Müller-Weiss disease (MWD) is a rare, degenerative condition affecting the navicular bone.
- Current diagnostic and terminological practices for MWD require refinement.
Purpose of the Study:
- To enhance awareness of Müller-Weiss disease among medical professionals, particularly radiologists.
- To advocate for standardized terminology and reporting methods for MWD.
- To guide treatment decisions based on foot alignment.
Main Methods:
- Review of current literature and clinical practices related to Müller-Weiss disease.
- Analysis of diagnostic challenges and proposed terminological changes.
- Discussion of treatment considerations, including surgical interventions.
Main Results:
- The terms 'bipartite navicular' and 'Brailsford's osteochondritis' should be discontinued for end-stage MWD.
- Geographic variations in MWD presentation exist.
- The term 'paradoxic pes planovarus' should be used cautiously, ensuring varus is present before surgery.
Conclusions:
- Increased medical community awareness, especially among radiologists, is vital for early MWD diagnosis.
- Standardized reporting using Wong groups and Maceira stages is essential for consistent outcome assessment.
- Global collaboration is needed to elucidate MWD etiology and establish treatment gold standards.
Related Concept Videos
01:09Directing Effect of Substituents: meta-Directing Groups
6.0K
Substituents on the benzene ring that direct an incoming electrophile to undergo substitution at the meta position are called meta directors. All meta directors either have a positive charge on the atom directly bonded to the ring or a partial positive charge. These groups function by withdrawing electrons from the ring through inductive and resonance effects. Consider the carbocation intermediates formed upon the addition of an electrophile on nitrobenzene at the...
6.0K
01:14Directing Effect of Substituents: ortho–para-Directing Groups
8.5K
Ortho–para directors are substituent groups attached to the benzene ring and direct the addition of an electrophile to the positions ortho or para to the substituent. All electron-donating groups are considered ortho–para directors. They donate electrons to the ring and make the ring more electron-rich. The ring is therefore susceptible to the addition of electrophiles. Substituents such as amino, hydroxy, or alkoxy, containing lone pairs on the atom adjacent to the ring, donate...
8.5K
01:14Directional Terms
16.3K
Directional terms are essential for describing the relative locations of different body structures. For instance, an anatomist might describe one band of tissue as "inferior to" another, or a physician might describe a tumor as "superficial to" a deeper body structure. These terms often use comparative terms in pairs to trace out the relative locations of one body part to another or descriptions of body tissues like the deeper ones from superficially present with reference to...
16.3K
01:25Directional Relays
612
Directional relays, essential for managing unidirectional fault currents, enhance the safety and efficiency of power systems. On power lines equipped with directional relays, faults downstream (to the right) of the current transformer typically cause the fault current to lag the bus voltage by approximately 90 degrees, known as the forward direction. In contrast, upstream (left-side) faults may result in the fault current leading the bus voltage by nearly 90 degrees, termed the reverse...
612
01:30Inflammatory Bowel Disease II: Crohn's Disease
1.1K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.1K
01:11Direct Motor Pathways
4.5K
The direct motor pathways, also known as the pyramidal tracts, are a group of neural pathways that originate in the brain and descend through the spinal cord. They control the voluntary movement of the body. There are two major direct motor pathways: the corticospinal and the corticobulbar tracts.
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
4.5K