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Updated: Jan 31, 2026

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Isolation of Primary Mouse Retinal Glial Müller Cells
Published on: August 30, 2024
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Imaging of Müller-Weiss Disease
Noel Napier1, Nicholas Alexander Napier2
1Department of Radiology, Ulster Independent Clinic, 245 Stranmillis Road, Belfast, Northern Ireland BT9 5JH, UK.
Foot and Ankle Clinics
|January 29, 2026
Summary
Müller-Weiss disease (MWD) is a rare foot condition with unknown causes. Advanced imaging like CT and SPECT-CT can help identify affected joints for targeted surgical treatment.
Area of Science:
- Orthopedics
- Radiology
- Medical Imaging
Background:
- Müller-Weiss disease (MWD) is a complex clinical condition with an unclear etiology.
- Initial diagnosis relies on dorsoplantar and lateral weight-bearing radiographs.
- The Maceira and Rochera staging system (2004) uses radiographs but doesn't correlate with clinical symptoms.
Purpose of the Study:
- To explore advanced imaging techniques for evaluating Müller-Weiss disease.
- To determine the utility of CT and SPECT-CT in identifying actively involved joints.
- To assess the role of these advanced modalities in guiding corrective arthrodesis.
Main Methods:
- Review of diagnostic imaging modalities for MWD.
- Analysis of the application of Computed Tomography (CT) and Single-Photon Emission Computed Tomography (SPECT)-CT.
- Correlation of imaging findings with potential surgical interventions.
Main Results:
- Standard radiographic staging for MWD shows poor correlation with clinical presentation.
- CT and SPECT-CT offer detailed joint evaluation in MWD.
- These advanced imaging techniques can pinpoint actively involved joints for surgical planning.
Conclusions:
- CT and SPECT-CT are valuable tools for assessing joint involvement in Müller-Weiss disease.
- Advanced imaging aids in planning selective corrective arthrodesis for MWD.
- Further understanding of MWD etiology is needed, but advanced imaging improves management.
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