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Updated: Jan 31, 2026

X-ray Dose Reduction through Adaptive Exposure in Fluoroscopic Imaging
Published on: September 11, 2011
Mass Dose Effects in FAP-Directed Imaging: Influence of Administered Dose of [68Ga]Ga-LNTH-1363S on Image Quality
Johanna S Enke1,2, Jan Baessler1, Gitasha Chand3
1Nuclear Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
Abstract:
Recent advances in fibroblast activation protein imaging have led to the development of new fibroblast activation protein-targeting radiotracers. This study investigates the mass dose effects of [68Ga]Ga-LNTH-1363S on image quality. Methods: In this retrospective evaluation of 39 patients with various oncologic diseases (including breast cancer and sarcoma), different administered mass doses (30, 75, 90, and 100 μg) of [68Ga]Ga-LNTH-1363S were visually and quantitatively (blood pool SUVmean, lesion SUVmax, and tumor-to-blood pool ratios [TBRs]) assessed. Results: Lower peptide masses were associated with prominent blood pooling in [68Ga]Ga-LNTH-1363S PET imaging and reduced TBRs, whereas higher mass doses yielded superior image quality because of lower mean tracer accumulation in the blood pool and therefore higher TBRs. Conclusion: These observations provide evidence that biodistribution and imaging quality are dependent on the administered mass dose. Further studies are warranted to validate these findings.
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