Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Thyroid Gland01:23

The Thyroid Gland

7.6K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
7.6K
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

5.6K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
5.6K
Cable Subjected to Its Own Weight01:13

Cable Subjected to Its Own Weight

797
Overhead power transmission lines rely on cables to carry electricity across large distances. To ensure the stability and functionality of these lines, it is crucial to understand the shape and tension experienced by the cables under the influence of their weight.
A generalized loading function is employed to analyze a cable subjected to its own weight. This function considers the force acting along the cable's arc length rather than its projected length, providing a more accurate...
797
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

7.8K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
7.8K
Cable Subjected to Concentrated Loads01:28

Cable Subjected to Concentrated Loads

1.4K
Flexible cables are commonly used in various applications for support and load transmission. Consider a cable fixed at two points and subjected to multiple vertically concentrated loads. Determine the shape of the cable and the tension in each portion of the cable, given the horizontal distances between the loads and supports.
1.4K
Cable Subjected to a Distributed Load01:24

Cable Subjected to a Distributed Load

1.1K
The analysis of suspension bridges is a complex and critical process that involves multiple factors, including the shape and tension of the main cables. The main cables of suspension bridges are subjected to distributed loads, which result in changes in tensile forces and deformation of the cable. These loads must be carefully considered to ensure that the bridge is safe and capable of supporting the weight of different loads.
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrated multicompartment urinary long non-coding RNAs profiling (cellular, cell-free, and extracellular vesicle) for better differential diagnosis of biopsy-proven diabetic and non-diabetic kidney disease beyond conventional markers.

BMJ open diabetes research & care·2026
Same author

Incidence of Concomitant Bacterial Infection in Hospitalized Patients Admitted Through the Emergency Department with A Positive Viral Respiratory Panel.

The Journal of emergency medicine·2026
Same author

Effect of mouthguard use and jaw clenching on athletic strength.

General dentistry·2026
Same author

Screening and Reactivation of Chagas Disease Among Solid Organ Transplant Candidates and Recipients: A 10-Year Single Center Experience in Florida.

Transplant infectious disease : an official journal of the Transplantation Society·2026
Same author

Effectiveness of Artificial Intelligence Models for Detection of Vertical Root Fractures: A Systematic Review.

Journal of endodontics·2026
Same author

Study of oral microbiome by next generation sequencing in T1DM adolescents with periodontal disease.

Acta diabetologica·2026

Related Experiment Video

Updated: Jan 31, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

2.5K

DYRK1A Expression and Thyroid Dysfunction in Subjects With Down Syndrome.

Akshay Khatri1, Susmita Dutta1, Astha Mukhopadhyay1

  • 1Department of Endocrinology and Metabolism, IPGME & R, Kolkata, India.

Clinical Endocrinology
|January 29, 2026
PubMed
Summary

DYRK1A gene is overexpressed in individuals with Down syndrome (DS) and hypothyroidism. This occurs in both early-onset non-autoimmune and later-onset autoimmune forms of the condition.

Keywords:
DYRK1ADown syndromeautoimmunityhypothyroidism

More Related Videos

Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

2.3K
Minimal Invasive Resection of Large Retrosternal Thyroid Goiter
04:09

Minimal Invasive Resection of Large Retrosternal Thyroid Goiter

Published on: September 20, 2024

936

Related Experiment Videos

Last Updated: Jan 31, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

2.5K
Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

2.3K
Minimal Invasive Resection of Large Retrosternal Thyroid Goiter
04:09

Minimal Invasive Resection of Large Retrosternal Thyroid Goiter

Published on: September 20, 2024

936

Area of Science:

  • Endocrinology
  • Genetics
  • Immunology

Background:

  • Thyroid dysfunction is prevalent in Down syndrome (DS), with its onset and causes often unclear.
  • The DYRK1A gene is implicated in thyroid development and immune function in DS, potentially influencing autoimmune diseases.

Purpose of the Study:

  • To investigate the expression of the DYRK1A gene in individuals with Down syndrome (DS) and hypothyroidism.
  • To correlate DYRK1A gene expression with the age of onset and autoimmune status in DS patients with hypothyroidism.

Main Methods:

  • A cross-sectional study involving five groups: DS with hypothyroidism, DS with euthyroidism, congenital hypothyroidism (non-DS), autoimmune hypothyroidism (non-DS), and healthy controls.
  • Assessment included medical history, age of onset, thyroid function tests, antibody levels, and DYRK1A gene expression analysis.

Main Results:

  • Individuals with DS and hypothyroidism showed significantly higher DYRK1A expression (6.33-fold) compared to euthyroid DS individuals.
  • DYRK1A expression was elevated in both anti-TPO-positive (5.17-fold) and anti-TPO-negative (7.27-fold) DS hypothyroidism groups compared to controls.
  • Early-onset hypothyroidism (<1 year) in DS was predominantly non-autoimmune (anti-TPO negative), while later-onset disease (>3 years) was often autoimmune (anti-TPO positive).

Conclusions:

  • DYRK1A gene is overexpressed in Down syndrome (DS) patients with hypothyroidism.
  • This overexpression is observed across both early-onset, non-autoimmune hypothyroidism and later-onset, autoimmune hypothyroidism in individuals with DS.