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New complex coacervates act as fast-acting underwater adhesives. These bioactive materials, made from polyelectrolytes and antibiotics, offer strong adhesion and sustained drug release for antibacterial applications.

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Area of Science:

  • Materials Science
  • Biotechnology
  • Polymer Chemistry

Background:

  • Fast-acting underwater adhesives are crucial for various applications.
  • Complex coacervates show promise as adhesives in wet environments.
  • Developing robust and bioactive adhesives remains a challenge.

Purpose of the Study:

  • To create novel complex coacervates for instant underwater adhesion.
  • To investigate the adhesive properties and salt resistance of these coacervates.
  • To evaluate the potential for sustained antibiotic release and antibacterial activity.

Main Methods:

  • Complexation of negative polyelectrolytes (poly(styrenesulfonate), PSS, and poly(acrylamidomethylpropanesulfonate), PAMPS) with positively charged antibiotics (neomycin and streptomycin).
  • Characterization of viscoelastic properties and adhesion strength under physiological conditions (0.15 M NaCl, 37 °C).
  • Assessment of salt resistance and antibiotic release kinetics using quantitative NMR.

Main Results:

  • Coacervates exhibited ideal viscoelastic properties for pressure-sensitive adhesion.
  • Adhesion strength reached up to 100 kPa and adhesion energy up to 80 J m-2.
  • Materials demonstrated salt resistance up to 1.7 M NaCl and sustained antibiotic release, killing bacteria.

Conclusions:

  • Introduced novel underwater bioactive instant adhesive coacervates.
  • Demonstrated competitive adhesive properties and salt resistance.
  • Highlighted the potential for sustained drug delivery from these complex coacervates.