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Updated: Jan 31, 2026
07:26
Intracranial Subarachnoidal Route of Infection for Investigating Roles of Streptococcus suis Biofilms in Meningitis in a Mouse Infection Model
Published on: July 1, 2018
7.7K
Group A Streptococcus Meningitis, United States, 1997-2022
Emerging Infectious Diseases
|January 30, 2026
Summary
Group A Streptococcus (GAS) can cause meningitis, a severe infection with a high fatality rate. Awareness is crucial as clindamycin resistance in GAS meningitis is increasing.
Area of Science:
- Infectious Diseases
- Microbiology
- Epidemiology
Background:
- Group A Streptococcus (GAS) is a known pathogen but infrequently recognized as a cause of meningitis.
- Invasive GAS infections can lead to severe outcomes, including meningitis.
Purpose of the Study:
- To determine the incidence and case-fatality rates (CFRs) of Group A Streptococcus meningitis in the United States.
- To analyze antimicrobial resistance patterns, specifically for clindamycin, in GAS meningitis isolates over time.
Main Methods:
- Analysis of GAS meningitis cases reported by ten sites in the Active Bacterial Core Surveillance network (1997-2022).
- Calculation of annual incidence and CFRs.
- Whole-genome sequencing to determine antimicrobial resistance profiles.
Main Results:
- Annual incidence of GAS meningitis ranged from 0.02 to 0.07 cases/100,000 persons, with the highest incidence in infants (<1 year).
- GAS meningitis exhibited a higher CFR (19.4%) compared to other common meningitis pathogens.
- Clindamycin resistance in GAS meningitis isolates significantly increased from 3.2% (1997-2002) to 17.7% (2018-2022).
Conclusions:
- Group A Streptococcus meningitis is an uncommon but severe manifestation of invasive GAS disease.
- Healthcare providers should maintain a high index of suspicion for GAS meningitis due to its significant CFR.
- The rising clindamycin resistance in GAS meningitis necessitates careful consideration of treatment strategies.
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