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Hydrogel Microspheres with Gut-Adaptive Structures for Efficient Probiotic Delivery and Gut-Targeted Release.

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New hydrogel microspheres protect probiotics in the gut. These gut-adaptive structures enhance probiotic survival and colonization, offering a promising delivery system for gut health.

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Area of Science:

  • Biomaterials Science
  • Microbiology
  • Gastroenterology

Background:

  • Oral probiotics regulate gut microbiota but face challenges due to the harsh digestive environment.
  • Existing polysaccharide hydrogels for probiotic delivery have limitations like poor structural integrity and premature release.

Purpose of the Study:

  • To develop novel gut-adaptive hydrogel microspheres (GG/GN-TA HMs) for enhanced probiotic protection and targeted oral delivery.
  • To improve probiotic survival and efficacy in the gastrointestinal tract.

Main Methods:

  • Created hydrogel microspheres using gellan gum (GG) and β-glucan-tannic acid (GN-TA).
  • Utilized TA-Ca2+ metal-phenol networks for structural enhancement and gut-targeting properties.
  • Evaluated microsphere integrity at low pH and their disassembly in the gut environment.
  • Assessed therapeutic effects in a colitis mouse model.

Main Results:

  • GG/GN-TA HMs demonstrated excellent structural integrity at low pH and gut-specific disassembly.
  • The system enabled probiotic survival in harsh conditions and promoted colon colonization.
  • Probiotic-loaded GG/GN-TA HMs significantly alleviated gut inflammation, repaired the gut barrier, and remodeled gut microbiota in colitis mice.

Conclusions:

  • GG/GN-TA HMs offer a robust system for probiotic protection and targeted delivery, overcoming limitations of conventional methods.
  • The developed hydrogel microspheres promote probiotic-prebiotic synergy for effective gut health management.
  • This system shows significant potential for therapeutic applications in inflammatory bowel diseases and gut microbiota modulation.