Related Experiment Video
Updated: Jan 31, 2026
07:41
Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
Published on: July 12, 2024
3.6K
Fabrication of 3D-Printed Adhesive Microneedle Patch Loaded with Codoped Hydroxyapatite in Deep-Tissue Infective
Anjali Upadhyay1, Debarati Kayal1, Snehasish Mandal1
1School of Biomedical Engineering, Indian Institute of Technology (BHU), Varanasi, Uttar Pradesh 221005, India.
ACS Applied Materials & Interfaces
|January 30, 2026
Summary
A novel microneedle patch (MNP) using hydroxyapatite (HAP) enhanced wound healing. This innovative MNP promotes rapid tissue repair and hemostasis, offering potential for chronic wound treatment.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Tissue Engineering
Background:
- Deep-tissue wound healing is hindered by poor therapeutic delivery.
- Current microneedle patches (MNPs) lack advanced therapeutics, adhesion, and natural biomaterials.
- Hydroxyapatite (HAP) shows promise for tissue regeneration due to its bioactive properties.
Purpose of the Study:
- To synthesize and evaluate novel hydroxyapatite (HAP) biomaterials for wound healing applications.
- To develop an adhesive microneedle patch (MNP) incorporating optimized HAP for enhanced therapeutic delivery.
- To assess the efficacy of the MNP in promoting hemostasis and skin wound repair.
Main Methods:
- Synthesized hexagonal HAP codoped with cerium (Ce) and magnesium (Mg) at varying concentrations.
- Conducted in vitro cytotoxicity and antibacterial assays to identify lead HAP composition.
- Fabricated adhesive MNPs using Digital Light Processing (DLP) 3D printing with the lead HAP formulation.
- Evaluated MNP efficacy in vivo using an infective rat model for liver hemostasis and skin wound repair.
Main Results:
- 2.5Ce-2.5Mg codoped HAP exhibited minimal cytotoxicity and maximal in vitro antibacterial activity.
- The MNP incorporating 2.5Ce-2.5Mg codoped HAP demonstrated rapid liver hemostasis.
- Significant repair of skin wounds was observed within 12 days in the in vivo model.
- The MNP+2.5Ce-2.5Mg HAP formulation showed strong potential for chronic wound repair.
Conclusions:
- Codoping HAP with Ce and Mg, particularly at 2.5Ce-2.5Mg, yields a promising biomaterial for wound healing.
- DLP 3D printed adhesive MNPs loaded with optimized HAP effectively deliver therapeutics for deep-tissue repair.
- The developed MNP+2.5Ce-2.5Mg HAP shows significant potential for clinical translation in accelerating chronic wound healing.
Related Concept Videos
01:14Adhesion
44.3K
Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
Capillary action is a result of water’s adhesive tendencies. When a narrow...
Capillary action is a result of water’s adhesive tendencies. When a narrow...
44.3K
01:02Long-patch Base Excision Repair
8.0K
Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:
8.0K
01:18Patch Clamp
6.5K
Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...
6.5K
01:19Impact Loading
693
Impact loading occurs when a moving object collides with a stationary structure, such as a rod with a uniform cross-sectional area fixed at one end. Under these conditions, the rod absorbs the kinetic energy from the striking object, leading to deformation and subsequent stress development. As the rod returns to its original position and reaches maximum stress, the absorbed energy, initially manifested as kinetic energy, transforms entirely into strain energy.
In cases of elastic deformation,...
In cases of elastic deformation,...
693
01:14Cell Adhesion in Plants
3.3K
Plants have rigid cell walls that are made up of cell wall polysaccharides that mediate cell-cell adhesion. The primary cell walls of plants consist of two independent and interacting polysaccharide networks: a pectin matrix that embeds the second network comprising cellulose and hemicelluloses.
Pectins are complex heteropolymers mainly composed of negatively-charged α-D-glucopyranosyl uronic acid and some neutral glycosyl residues such as α-L-rhamnopyranose, α-L-arabinofuranose,...
Pectins are complex heteropolymers mainly composed of negatively-charged α-D-glucopyranosyl uronic acid and some neutral glycosyl residues such as α-L-rhamnopyranose, α-L-arabinofuranose,...
3.3K
01:19Distributed Loads
970
Distributed loads are a common type of load that engineers and scientists encounter in various practical situations. Distributed loads often refer to a type of load spread over a surface or a structure and can be modeled as continuous force per unit area.
For example, consider a bookshelf filled with books stacked vertically adjacent to each other. The weight of the books is evenly distributed over the length of the shelf. As a result, the pressure at different locations on the surface of the...
For example, consider a bookshelf filled with books stacked vertically adjacent to each other. The weight of the books is evenly distributed over the length of the shelf. As a result, the pressure at different locations on the surface of the...
970