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Published on: January 8, 2020
Prognostic Evaluation of the Charlson Comorbidity Index for Breast Cancer Patients by Propensity Score Matching
Yoshiaki Shinden1, Yuka Eguchi2, Hiroko Toda2
1Department of Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. yoshinden@gmail.com.
Purpose:
The Charlson Comorbidity Index (CCI) is associated with the prognosis of patients with breast cancer. However, comorbidities are often confounded by both age and treatment course; therefore, it is essential to eliminate the influence of these factors. We analyzed the relationship between CCI scores and breast cancer prognosis using propensity score matching (PSM).
Methods:
We retrospectively analyzed 1,403 patients with primary breast cancer who underwent curative surgery. After PSM, 764 patients were selected for analysis of clinicopathological and prognostic factors.
Results:
After PSM, prognosis was compared between groups according to several CCI cutoff values. No significant differences in disease-free survival or breast cancer-specific overall survival (OS) were observed according to the CCI score. Similarly, no significant differences in OS were observed between the high- and low-CCI groups at CCI cutoff values of 1 and 2. However, at a CCI cutoff value of 3, OS was significantly worse in patients with higher CCI scores.
Conclusion:
Among patients with breast cancer, those with CCI scores ≥ 3 often experience mortality due to diseases other than breast cancer.
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