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Updated: Jan 31, 2026
06:45
Author Spotlight: Characterizing Porous Materials for Aiding the Development of Robust Metal-Organic Frameworks with Adsorption Behavior
Published on: March 8, 2024
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Size-Controllable Curcumin-Based Metal-Organic Framework-Integrated Multifunctional Hydrogel for Wound Healing
Yuxin Wang1, Haonan Hu1, Bingjie Sun1
1State Key Laboratory of Advanced Technology For Material Synthesis and Processing, Wuhan University of Technology, Wuhan, China.
Advanced Healthcare Materials
|January 30, 2026
Summary
Researchers developed novel curcumin-based metal-organic frameworks (Cu/Zn-Cur MOFs) to enhance wound healing. These nanoparticles effectively combat bacterial infections and oxidative stress, offering a promising solution for improved wound care.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Wound Healing Research
Background:
- Bacterial infections and oxidative stress hinder wound healing.
- Curcumin shows antibacterial and antioxidant potential but suffers from poor solubility and bioavailability.
- Nanoparticulate formulations offer a strategy to overcome curcumin's limitations.
Purpose of the Study:
- To develop a novel curcumin-based metal-organic framework (MOF) for improved wound healing applications.
- To create carrier-free curcumin nanoparticles with enhanced antioxidant and antibacterial properties.
- To integrate these nanoparticles into a hydrogel for a multifunctional wound dressing.
Main Methods:
- Fabrication of curcumin-based metal-organic frameworks (Cu/Zn-Cur MOFs) using a "mixing-diluting" strategy.
- Characterization of MOF morphology, antioxidant activity (eliminating •OH and •O2- radicals), and antibacterial efficacy against Gram-positive and Gram-negative bacteria.
- Integration of Cu/Zn-Cur MOFs into a tissue adhesive hydrogel to create a multifunctional wound dressing (PCEM).
Main Results:
- Cu/Zn-Cur MOFs exhibited spherical morphology and potent antioxidant activity.
- The MOFs demonstrated broad-spectrum antibacterial activity against various bacterial strains.
- The resulting PCEM wound dressing showed biocompatibility and promoted infected wound healing in vivo.
Conclusions:
- A novel strategy for synthesizing carrier-free curcumin nanoparticles was successfully developed.
- Cu/Zn-Cur MOFs offer a promising approach to enhance the therapeutic application of insoluble natural compounds like curcumin.
- The developed multifunctional wound dressing shows potential for clinical use in promoting infected wound healing.
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