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Structure-function relationships across scales: implications for atlases.

R Todd Constable1

  • 1Department of Radiology and Bioimaging Science, Yale University School of Medicine, New Haven, CT, United States.

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|January 30, 2026
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Summary
This summary is machine-generated.

Neuroscience connects brain structure and function across scales. Understanding this relationship, from cells to neural ensembles, is key for behavior and advancing brain models.

Keywords:
atlasatlasesbraincellsfunctional imagingorganizationstructure

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Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Systems Neuroscience

Background:

  • Neuroscience investigates the brain-behavior link through structural and functional organization.
  • Cellular-level studies form the neurobiological basis for understanding brain function.
  • A comprehensive view requires integrating molecular, cellular, and network-level data.

Purpose of the Study:

  • To review the relationship between structural and functional organization across different scales in the brain.
  • To establish a common language for neuroscientists operating at various levels of analysis.
  • To highlight the importance of scale-dependent understanding in neuroscience.

Main Methods:

  • Review of existing literature on structural and functional organization in neuroscience.
  • Analysis of scale-dependent complexities in brain function.
  • Conceptual framework development for integrating multi-scale neuroscience data.

Main Results:

  • Structure unequivocally constrains function at the cellular level.
  • Brain function at meso- and macro-scopic scales involves complex dynamic interactions of neuronal ensembles.
  • Scale differences present significant challenges for current representational models.

Conclusions:

  • Recognizing scale-specific complexities is crucial for advancing neuroscience.
  • A unified understanding across scales is essential for comprehensive brain models.
  • Bridging the gap between cellular structure and network-level function remains a key challenge.