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Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
Published on: January 12, 2022
Systemic Immune-Inflammation Index as a Marker of Activity in Behcet's Uveitis
Doaa Maamoun Ashour1, Mohamed Rezk Mohamed2, Nesrin Said Madkour1
1Department of Ophthalmology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
|January 30, 2026
Summary
The Systemic Immune-Inflammation Index (SII) is a promising biomarker for detecting active uveitis in Behcet's disease (BD). Higher SII levels were observed in active BD uveitis patients compared to inactive disease and healthy controls.
Area of Science:
- Ophthalmology
- Immunology
- Rheumatology
Background:
- Behcet's disease (BD) is an immune-mediated condition frequently causing ocular inflammation (uveitis).
- Assessing uveitis activity in BD can be complex.
- The Systemic Immune-Inflammation Index (SII) is a novel biomarker not yet studied in BD uveitis.
Purpose of the Study:
- To evaluate Systemic Immune-Inflammation Index (SII) levels in Behcet's disease (BD) patients with active uveitis.
- To assess other inflammatory biomarkers derived from full blood count (FBC) in active BD uveitis.
- To determine if SII can serve as a biomarker for uveitis activity in BD.
Main Methods:
- A case-control study involving 58 participants: 24 with active BD uveitis, 15 with inactive BD, and 19 healthy controls.
- Collected venous blood samples for full blood count (FBC) analysis.
- Calculated Neutrophil-Lymphocyte Ratio (NLR), Platelet-Lymphocyte Ratio (PLR), and Systemic Immune-Inflammation Index (SII).
Main Results:
- Systemic Immune-Inflammation Index (SII) was significantly higher in active BD uveitis patients compared to inactive BD patients (P < .001) and healthy controls (P = .002).
- A cutoff SII value > 701.72 demonstrated 79.17% sensitivity and 100% specificity for active uveitis.
- Neutrophil-Lymphocyte Ratio (NLR) and Platelet-Lymphocyte Ratio (PLR) were also elevated in the active uveitis group.
Conclusions:
- Systemic Immune-Inflammation Index (SII) is significantly elevated in Behcet's disease (BD) patients with active uveitis.
- SII shows potential as a valuable biomarker for identifying active uveitis in BD.
- Further research is warranted to correlate SII levels with disease severity in BD uveitis.
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