Related Experiment Video For Clinical efficacy
Updated: Jan 31, 2026

Establishing 3D Endometrial Organoids from the Mouse Uterus
Published on: January 6, 2023
Advances in the molecular mechanisms underlying progestin resistance in endometrial cancer
Jie Liu1, Jingyi Zhou1, Yiqin Wang1
1Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing 100044, China.
Abstract:
The incidence of endometrial cancer (EC) has been on the rise, with a notable increase observed in younger female population. Approximately 80% of EC patients are associated with endometrial hyperplasia, a condition characterized by excessive stimulation from unopposed estrogen. Progestin, as the antagonist of estrogen, is recommended for patients with fertility conservation requirements. However, some patients may exhibit insensitivity to progestin treatment, and those with comorbidities such as obesity and diabetes may experience suboptimal therapeutic effects. To improve the efficacy of progestin treatment and address the fertility needs of patients, it is imperative to elucidate the underlying mechanisms of progestin insensitivity in EC. In this review, we explore the role of progestin in EC and its clinical effectiveness. We discuss the factors contributing to progestin insensitivity, highlight recent advancements in research aimed at enhancing treatment sensitivity, and propose potential avenues for future investigation.
Related Concept Videos
Treatment Resistant Cancers
Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Mechanisms of Retrovirus-induced Cancers
Reaction Mechanisms
For instance, the decomposition of ozone appears to follow a mechanism with two steps:
Resistivity
Resistance

