Related Experiment Video
Updated: Jan 31, 2026
07:42
An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat
Published on: May 19, 2020
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Obstructive hypertrophic cardiomyopathy: current perspectives on mitral leaflet shortening
Katherine G Phillips1, Joshua A Scheinerman1, Daniele Massera2
1Department of Cardiothoracic Surgery, NYU Langone Health, New York, NY 10016 USA.
Indian Journal of Thoracic and Cardiovascular Surgery
|January 30, 2026
Summary
Hypertrophic cardiomyopathy (HCM) surgery now includes mitral leaflet shortening alongside septal myectomy. This comprehensive approach improves outcomes for left ventricular outflow tract obstruction (LVOTO).
Area of Science:
- Cardiology
- Cardiac Surgery
- Genetics
Background:
- Hypertrophic cardiomyopathy (HCM) is a common monogenic heart disease, often underdiagnosed.
- Left ventricular outflow tract obstruction (LVOTO) in HCM is complex, involving more than just septal hypertrophy.
- The mitral valve's role in LVOTO is increasingly recognized.
Purpose of the Study:
- To review current evidence on surgical management of obstructive HCM.
- To highlight the role of mitral leaflet shortening in treating LVOTO.
- To discuss comprehensive surgical strategies for HCM.
Main Methods:
- Review of current clinical evidence and surgical experiences.
- Analysis of historical and contemporary approaches to LVOTO in HCM.
- Focus on mitral valve interventions combined with septal myectomy.
Main Results:
- Mitral leaflet shortening (plication or ReLex) combined with septal myectomy improves outcomes.
- These strategies reduce mitral regurgitation and alleviate LVOTO.
- Combined approaches show excellent mid-term survival rates.
Conclusions:
- Mitral leaflet shortening is a key component of modern obstructive HCM surgery.
- Comprehensive surgical strategies integrating mitral valve and septal interventions are effective.
- Improved understanding of mitral valve dynamics enhances HCM treatment outcomes.
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