Related Experiment Video

Updated: Jan 31, 2026

An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat
07:42

An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat

Published on: May 19, 2020

7.5K

Obstructive hypertrophic cardiomyopathy: current perspectives on mitral leaflet shortening

Katherine G Phillips1, Joshua A Scheinerman1, Daniele Massera2

  • 1Department of Cardiothoracic Surgery, NYU Langone Health, New York, NY 10016 USA.

Indian Journal of Thoracic and Cardiovascular Surgery
|January 30, 2026
PubMed

Insights

Hypertrophic cardiomyopathy (HCM) surgery now includes mitral leaflet shortening alongside septal myectomy. This comprehensive approach improves outcomes for left ventricular outflow tract obstruction (LVOTO).

Area of Science:

  • Cardiology
  • Cardiac Surgery
  • Genetics

Background:

  • Hypertrophic cardiomyopathy (HCM) is a common monogenic heart disease, often underdiagnosed.
  • Left ventricular outflow tract obstruction (LVOTO) in HCM is complex, involving more than just septal hypertrophy.
  • The mitral valve's role in LVOTO is increasingly recognized.

Purpose of the Study:

  • To review current evidence on surgical management of obstructive HCM.
  • To highlight the role of mitral leaflet shortening in treating LVOTO.
  • To discuss comprehensive surgical strategies for HCM.

Main Methods:

  • Review of current clinical evidence and surgical experiences.
  • Analysis of historical and contemporary approaches to LVOTO in HCM.
  • Focus on mitral valve interventions combined with septal myectomy.

Main Results:

  • Mitral leaflet shortening (plication or ReLex) combined with septal myectomy improves outcomes.
  • These strategies reduce mitral regurgitation and alleviate LVOTO.
  • Combined approaches show excellent mid-term survival rates.

Conclusions:

  • Mitral leaflet shortening is a key component of modern obstructive HCM surgery.
  • Comprehensive surgical strategies integrating mitral valve and septal interventions are effective.
  • Improved understanding of mitral valve dynamics enhances HCM treatment outcomes.

Keywords:
Hypertrophic cardiomyopathyLeft ventricular outflow tract obstructionSeptal myectomySystolic anterior motion of the mitral valve

More Related Videos

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

4.3K
Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve09:13

Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve

Published on: June 14, 2017

13.4K

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
486
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
563
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
532
Psychodynamic Perspectives on Personality01:27

Psychodynamic Perspectives on Personality

The psychodynamic perspective in psychology asserts that most personality functions operate unconsciously, outside of awareness. This means that the motives and emotions driving behavior often remain hidden, automatically buried in the unconscious mind as a defense mechanism to shield us from psychological distress. According to this theory, the unconscious mind contains thoughts, memories, and emotions that are too disturbing to face directly.
Psychodynamic theorists argue that unconscious...
1.6K
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
442
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
603