Related Experiment Video
Updated: Jan 31, 2026
07:51
Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis
Published on: September 26, 2018
8.1K
Risk Factors and Management Strategies for Antipsychotic-Induced Weight Gain: A Prescriptive Review for Clinicians.
Nicolette Stogios1, Akash PrasannaKumar1, Kamna Mehra1
1Schizophrenia Division, Centre for Addiction and Mental Health, Toronto.
Focus (American Psychiatric Publishing)
|January 30, 2026
Summary
Antipsychotic-induced weight gain (AIWG) is a serious side effect of antipsychotic medications (APs). Early intervention, lifestyle changes, and novel therapies are crucial for managing and preventing AIWG in individuals with serious mental illness.
Area of Science:
- Pharmacology
- Metabolic Health
- Psychiatry
Background:
- Antipsychotic-induced weight gain (AIWG) significantly increases morbidity and mortality in patients with serious mental illness.
- Addressing metabolic side effects of antipsychotic medications (APs) is critical for patient well-being.
Purpose of the Study:
- To review risk factors and predictors of AIWG.
- To provide an overview of nonpharmacological and pharmacological therapies for AIWG.
- To emphasize the importance of prevention and system-level reforms.
Main Methods:
- Literature review of AIWG risk factors.
- Summary of evidence-based nonpharmacological and pharmacological interventions.
- Analysis of current clinical guidelines and emerging therapies.
Main Results:
- Age, prior AP exposure, and AP type are key AIWG determinants.
- Metabolic monitoring and lifestyle changes are primary interventions.
- Metformin is recommended off-label; novel agents show promise.
Conclusions:
- Prevention of AIWG may be more beneficial than treatment due to reversal challenges.
- System-level reforms in education and clinical services are essential for proactive monitoring and early intervention.
- Integrating evidence-based practices is vital for mitigating metabolic risks associated with APs.
Related Concept Videos
01:26Factors Affecting the Risk of Infection
13.5K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.5K
01:15Gain
410
Gain and phase shift are properties of linear circuits that describe the effect a circuit has on a sinusoidal input voltage or current. The circuit's behavior that contains reactive elements will depend on the frequency of the input sinusoid. As a result, it is observed that the gain and phase shift will all be frequency functions.
Gain:
Suppose Vin is the input and Vout is the output signal to a circuit.
Gain:
Suppose Vin is the input and Vout is the output signal to a circuit.
410
01:10Review and Preview
8.4K
In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
Percentiles are a type of fractile that partition data into...
8.4K
01:13Review and Preview
11.2K
Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
11.2K
01:02Prescription, Nonprescription and Orphan Drugs
1.3K
Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
1.3K
00:57Weighted Mean
6.3K
While taking the arithmetic, geometric, or harmonic mean of a sample data set, equal importance is assigned to all the data points. However, all the values may not always be equally important in some data sets. An intrinsic bias might make it more important to give more weightage to specific values over others.
For example, consider the number of goals scored in the matches of a tournament. While computing the average number of goals scored in the tournament, it may be more important to...
For example, consider the number of goals scored in the matches of a tournament. While computing the average number of goals scored in the tournament, it may be more important to...
6.3K