Related Experiment Video
Updated: Jan 31, 2026

NMR-Based Fragment Screening in a Minimum Sample but Maximum Automation Mode
Published on: June 4, 2021
The rise of NMR-integrated fragment-based drug discovery in China
Zihuan Li1, Lei Wang1, Jia Gao1
1Department of Oncology, The First Affiliated Hospital & School of Life Sciences, Ministry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, Hefei National Research Center for Interdisciplinary Sciences at the Microscale, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China.
Abstract:
Nuclear magnetic resonance (NMR) spectroscopy is an indispensable tool to probe weak protein-ligand interactions, which are key to the hit identification and hit-to-lead evolution in fragment-based drug discovery (FBDD). The integration of NMR technology in FBDD has facilitated the development of a diverse array of candidate compounds and FDA-approved drugs. Here, we summarized the rapid advancement and application of NMR techniques in contemporary China, which serves as a catalyst for the ongoing prosperousness of fragment-derived inhibitors against various targets.
Related Concept Videos
Drug Discovery: Overview
¹H NMR Signal Integration: Overview
Habitat Fragmentation
Rise of Liquid in a Capillary Tube
¹³C NMR: ¹H–¹³C Decoupling
A broadband decoupling technique is used to simplify these complex, sometimes overlapping, signals. Broadband decoupling relies on a...
Integration by Parts: Indefinite Integrals

