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Primary (AL) Amyloidosis Following COVID-19 Infection: A Case Report.
Nasrin Gholami1, Sepideh Tahsini Tekantapeh2, Amirreza Khalaji3
1Hematology and Oncology Research Center Tabriz University of Medical Sciences Tabriz Iran.
Clinical Case Reports
|January 30, 2026
Summary
Primary (AL) amyloidosis, a rare disorder, may develop after COVID-19 infection. This case highlights the potential link between SARS-CoV-2 and amyloidosis, emphasizing the need for clinical awareness.
Area of Science:
- Immunology
- Pathology
- Internal Medicine
Background:
- Primary (AL) amyloidosis involves immunoglobulin light chain deposition, causing organ dysfunction.
- SARS-CoV-2 infection can cause immune dysregulation, potentially promoting amyloid formation.
- Clinical evidence linking COVID-19 to amyloidosis is limited, necessitating further investigation.
Purpose of the Study:
- To report a novel case of primary (AL) amyloidosis following SARS-CoV-2 infection.
- To explore the potential pathomechanisms linking COVID-19 to amyloidogenesis.
- To raise clinical awareness of post-COVID-19 amyloidosis.
Main Methods:
- Case presentation of a 39-year-old male with progressive symptoms post-COVID-19.
- Diagnostic workup including imaging, liver biopsy with Congo red staining, and bone marrow analysis.
- Review of potential molecular mechanisms and supporting literature.
Main Results:
- The patient presented with weight loss, hepatosplenomegaly, and cholestatic liver enzymes 10 months after mild COVID-19.
- Liver biopsy confirmed amyloid deposition; bone marrow analysis revealed clonal plasma cells, diagnosing primary (AL) amyloidosis.
- Echocardiography showed amyloid infiltration causing left ventricular hypertrophy.
Conclusions:
- This case suggests a possible association between SARS-CoV-2 infection and the development of primary (AL) amyloidosis.
- Post-COVID-19 inflammatory responses may contribute to amyloid formation.
- Clinicians should consider amyloidosis in patients with relevant symptoms after SARS-CoV-2 infection, necessitating early diagnosis and management.
Keywords:
AL amyloidosisCOVID‐19SARS‐CoV‐2hepatosplenomegalyliver biopsypost‐viral amyloidogenesispost‐viral immune dysregulationprimary amyloidosisMore Related Videos
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