Cobalt-Catalyzed γ‑C-H Functionalization of Alcohols via Olefin-Tethered Radical Relay

Herein, we report a cobalt-catalyzed method for γ-selective C-H functionalization of aliphatic alcohols via a hydrogen atom transfer (HAT)-based radical relay. This strategy employs a readily available cobalt-salen catalyst under mild conditions, enabling diverse γ-C-H functionalization with excellent site-selectivity. Mechanistic insights were gained through spectroscopic experiments and DFT calculations, confirming the formation of carbon-centered radicals as key intermediates in the reaction pathway. This study offers a powerful tool for site-selective derivatization of alcohols and contributes to the development of sustainable and modular C-H functionalization strategies.