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Natural Products in Cancer Prevention and Therapy: Current Challenges and Future Directions
Ruimiao Qian1, Jun Ge1, Ni Fan1
1College of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine Tianjin China.
Medcomm
|January 30, 2026
Summary
Natural products offer multifaceted cancer interventions by targeting tumor metabolism and the tumor microenvironment (TME). This review synthesizes their applications across clinical phases, enhancing precision oncology strategies.
Area of Science:
- Oncology
- Pharmacology
- Natural Products Research
Background:
- Natural products are a vital source of bioactive compounds for cancer prevention, treatment, and supportive care.
- Their mechanisms involve direct cytotoxicity, metabolic pathway modulation, and influencing the tumor microenvironment (TME).
Purpose of the Study:
- To systematically review natural products' concurrent targeting of metabolic reprogramming and immune-stromal components in oncology.
- To delineate their therapeutic applications across the clinical continuum and explore innovative delivery strategies.
Main Methods:
- Literature review focusing on natural products like flavonoids, alkaloids, and terpenoids.
- Analysis of their impact on metabolic pathways (glucose, lipid, glutamine) and TME components (fibroblasts, ECM, immune cells).
- Examination of delivery systems (nanocarriers, codelivery) for enhanced bioavailability and synergistic combinations.
Main Results:
- Natural products disrupt core metabolic pathways and influence TME elements including cancer-associated fibroblasts, extracellular matrix, and immune cells.
- Innovative delivery strategies enhance bioavailability and enable synergistic combinations with conventional therapies.
Conclusions:
- Natural products play a significant role in multimodal cancer care, impacting metabolism and the TME.
- Integrating mechanistic insights with delivery strategies supports their use in biomarker-driven, precision oncology regimens.
Keywords:
cancer metabolic reprogrammingimmune modulationnatural productsprecision medicinetumor microenvironmentMore Related Videos
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