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Unravelling the Anticancer Potential of Schiff Base Functionalized Nanoparticles: Recent Developments and Future
Surbhi Yadav1, Astha Kamboj1, Bhanupriya Phogat1
1Department of Chemistry, Banasthali Vidyapith, Tonk, Rajasthan, India.
Journal of Biochemical and Molecular Toxicology
|January 30, 2026
Summary
Schiff base nanoparticles show promise for cancer therapy by enhancing drug efficacy and reducing toxicity. Further research is needed for precise design and clinical translation of these advanced nanomaterials.
Area of Science:
- Nanotechnology
- Materials Science
- Medicinal Chemistry
Background:
- Schiff bases are versatile organic compounds derived from carbonyl compounds and primary amines.
- These compounds are increasingly utilized as precursors for novel nanomaterials in cancer treatment.
- Nanoparticle formulations offer potential advantages over traditional cancer therapies.
Purpose of the Study:
- To review the synthesis of Schiff bases and their nanoparticle development.
- To discuss preparation methods, characterization techniques, and biological mechanisms of Schiff base nanoparticles.
- To highlight the potential and limitations of Schiff base-functionalized nanoparticles in oncology.
Main Methods:
- Literature review of Schiff base synthesis and nanoparticle formulation.
- Analysis of physicochemical characterization methods for Schiff base nanoparticles.
- Examination of biological pathways targeted by these nanoparticles in cancer cells.
Main Results:
- Schiff base nanoparticles demonstrate improved drug efficacy and reduced systemic toxicity compared to conventional treatments.
- Various methods exist for synthesizing Schiff bases and developing them into nanoparticles.
- These nanoparticles interact with key biological pathways influencing cancer cell survival.
Conclusions:
- Schiff base nanoparticles represent a promising area for targeted cancer therapy.
- Further research is essential for optimizing nanoparticle design and understanding long-term biological interactions.
- Bridging the gap between laboratory findings and clinical application is crucial for future success.
Keywords:
Schiff base functionalized nanoparticlesSchiff base—metal complexesanticancer activitycytotoxicitydrug deliverytargeted cancer therapyMore Related Videos
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