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Chemo-enzymatic Synthesis of N-glycans for Array Development and HIV Antibody Profiling
Published on: February 5, 2018
Chemo- and diastereoselective synthesis of spiro-iminoindoline-pyrazolines as potential antioxidant reagents
Yuan-Hang Tian1, Qi-Chun Yang1,2,3, Yu-Xuan Liu1
1Anti-infective Agent Creation Engineering Research Centre of Sichuan Province, Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu 610106, P. R. China. lijunlong709@hotmail.com.
Abstract:
The construction of spiro-iminoindoline-pyrazolines from readily available starting materials has garnered significant interest within the synthetic chemistry community. Herein, we report a chemo- and diastereoselective (2 + 3) and three-component formal (1 + 1 + 3) cascade cyclization strategy for their synthesis, demonstrating unprecedented CC chemoselectivity of nitrile imines toward α,β-unsaturated imines. This method delivers multifunctionalized products efficiently under mild conditions. Furthermore, preliminary antioxidant screening using the DPPH radical scavenging assay highlights their potential bioactivity.
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