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Uranyl-Enabled Photocatalytic C(sp3)-H Functionalization with Azoles
Yin-Ying Luo1, Shu-Yun Zhang1, Yan-Xin Jiang1
1College of Chemistry, Sichuan University, Chengdu 610064, China.
None:
Under mild conditions, uranyl nitrate catalyzed C(sp3)-center/azole coupling without external additives, offering a broad substrate scope and high yields (up to 95%). The method was further validated under sunlight and in scale-up experiments, highlighting its industrial potential. Experimental and theoretical studies show that uranyl nitrate acts via both hydrogen-atom transfer (HAT) and non-HAT concerted proton-electron transfer mechanisms. This approach provides a green, efficient protocol for C(sp3)-azole bond formation.
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