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Related Experiment Video

Updated: Jan 31, 2026

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A Review on Aptamer Feasibility in Aptasensor Developments for High-Performance Bioligand Analysis.

Thangavel Lakshmipriya1,2, Subash C B Gopinath2,3,4,5, Hemavathi Krishnan2

  • 1Department of Community Medicine, Saveetha Medical College & Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, India.

Critical Reviews in Analytical Chemistry
|January 30, 2026
PubMed
Summary

Aptamers, which are synthetic molecules, are used to create highly sensitive biosensors called aptasensors. These aptasensors can detect specific targets, offering a promising alternative to traditional antibody-based detection methods.

Keywords:
High-performance analysisligand-induced aptamersmedical diagnosisnanomaterialserological markers

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Area of Science:

  • Biotechnology
  • Nanotechnology
  • Analytical Chemistry

Background:

  • Aptamers are synthetic nucleic acid or peptide molecules selected through in vitro or in vivo methods.
  • They possess unique structural properties allowing for specific target binding and labeling.
  • Aptamers are increasingly utilized in sensor development due to their stability and ease of conjugation with nanomaterials.

Purpose of the Study:

  • To highlight the role of aptamers in developing advanced biosensing technologies.
  • To explore the potential of aptamers as recognition elements in high-performance analytical systems.
  • To position aptamers as a viable alternative to antibodies in sensor applications.

Main Methods:

  • Aptamers are generated using amplification and separation procedures from synthetic libraries.
  • Immobilization of aptamers on sensor platforms utilizes various functionalization chemistries.
  • Conjugation with nanomaterials enhances signal reporting for target detection.

Main Results:

  • Aptamer-based sensors (aptasensors) demonstrate enhanced sensitivity for target detection.
  • Various sensing systems leveraging aptamer-nanomaterial conjugates have been developed.
  • Aptasensors show promise for sensitive clinical and serological biomarker detection.

Conclusions:

  • Aptamers are versatile molecules for creating sensitive and specific aptasensors.
  • Aptasensors offer a high-throughput and potentially more efficient alternative to antibody-based detection.
  • The application of aptasensors is expanding in clinical diagnostics and biomarker analysis.