Related Experiment Video

Updated: Jan 31, 2026

Isolation and Profiling of MicroRNA-containing Exosomes from Human Bile
06:59

Isolation and Profiling of MicroRNA-containing Exosomes from Human Bile

Published on: June 13, 2016

10.9K

Advances in the study of the breast carcinoma exosomal microRNAs: From basic mechanisms to clinical applications

Zhi-Min Chen1, Peng Huang1, Dun-Yang Yang1

  • 1Department of Radiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian 362000, P.R. China.

International Journal of Oncology
|January 30, 2026
PubMed

Insights

Exosomal microRNAs (miRNAs) are crucial in breast cancer progression and treatment resistance. This review highlights their potential as biomarkers and therapeutic targets for precision medicine.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Breast carcinoma is a significant global health challenge.
  • Exosomal microRNAs (miRNAs) are increasingly recognized for their roles in breast cancer progression, metastasis, and treatment resistance.
  • Understanding exosomal miRNAs is vital for developing innovative diagnostic and therapeutic strategies.

Purpose of the Study:

  • To systematically review the multilevel roles of exosomal miRNAs in breast cancer, encompassing oncogenicity, tumor inhibition, and the regulation of breast carcinoma calcification.
  • To explore the potential of the exosomal miRNA-calcification axis as a link between tumor metabolism and pathological calcification.
  • To highlight exosomal miRNAs as non-invasive biomarkers and therapeutic targets in precision medicine.

Main Methods:

  • Systematic literature review and integration of existing research on exosomal miRNAs in breast cancer.
  • Analysis of mechanisms of action, including regulation of oncogenic/tumor-suppressive pathways and the tumor microenvironment.
  • Evaluation of therapeutic potential, including miRNA mimics and inhibitors, and their role in combination treatments.

Main Results:

  • Exosomal miRNAs significantly influence tumor progression, metastasis, and chemo-resistance in breast cancer.
  • These miRNAs regulate key oncogenic and tumor-suppressive pathways and modulate the tumor microenvironment.
  • Exosomal miRNAs are implicated in breast carcinoma calcification, suggesting a novel axis linking tumor metabolism and pathological calcification.

Conclusions:

  • Exosomal miRNAs represent promising non-invasive biomarkers for early detection and monitoring of breast cancer.
  • miRNA-based therapies, such as mimics and inhibitors, hold potential for enhancing treatment efficacy, particularly in combination therapies.
  • Further research is needed to optimize exosome isolation and miRNA detection methods for clinical translation and to refine exosome-targeted delivery systems.
Keywords:
biomarkerbreast carcinomacalcificationcombination therapyexosomal miRNAs

More Related Videos

Purification and microRNA Profiling of Exosomes Derived from Blood and Culture Media10:45

Purification and microRNA Profiling of Exosomes Derived from Blood and Culture Media

Published on: June 14, 2013

32.4K
Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells16:24

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

20.7K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.2K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.0K
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.3K
Review and Preview01:10

Review and Preview

In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
8.4K
Review and Preview01:13

Review and Preview

Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
11.2K
Energy Basics02:27

Energy Basics

Chemical reactions, such as those that occur when you light a match, involve changes in energy as well as matter.
47.6K