Related Experiment Video

Updated: Jan 31, 2026

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
10:43

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

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[Retracted] MicroRNA‑615‑5p targets insulin‑like growth factor 2 and exerts tumor‑suppressing functions in human

Bingyin Yang1, Rui Xie1, Shang-Nong Wu1

  • 1Department of Gastroenterology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China.

Oncology Reports
|January 30, 2026
PubMed

Insights

This article has been retracted due to significant data anomalies and lack of author response. The editor lost confidence in the oncology research findings.

Area of Science:

  • Oncology
  • Cell Biology
  • Scientific Publishing Ethics

Background:

  • A previously published article in Oncology Reports presented data from Transwell assays.
  • Concerns were raised regarding the similarity of cell groupings in Figures 2B, 2C, and 5A-D.

Purpose of the Study:

  • To investigate reported anomalies in Transwell data presented in a published oncology study.
  • To determine the validity of the presented data following reader-flagged similarities in cell images.

Main Methods:

  • Internal investigation of data presented in the original publication.
  • Review of Transwell assay data, specifically cell groupings in Figures 2 and 5.
  • Attempted communication with authors for clarification.

Main Results:

  • Anomalies were identified in the Transwell data, specifically strikingly similar cell groupings across multiple figures.
  • The observed similarities were deemed too extensive to be attributed to coincidence.
  • Authors did not provide a response to the editorial office regarding the data concerns.

Conclusions:

  • The Editor has retracted the article due to a lack of confidence in the data.
  • The retraction is based on the significant and unexplained data anomalies.
  • The findings highlight the importance of data integrity in scientific publications.
Keywords:
carcinogenesiscell motilityesophageal squamous cell carcinomainsulin-like growth factor 2microRNA‑615‑5p

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