Related Experiment Video

Updated: Jan 31, 2026

Stereotactic Intracranial Implantation and In vivo Bioluminescent Imaging of Tumor Xenografts in a Mouse Model System of Glioblastoma Multiforme
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[Retracted] miR‑124‑3p inhibits the viability and motility of glioblastoma multiforme by targeting RhoG

Shan Cai1, Chao-Jia Shi1, Jian-Xiang Lu1

  • 1Department of Neurosurgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, P.R. China.

International Journal of Molecular Medicine
|January 30, 2026
PubMed

Insights

This paper has been retracted due to concerns about the specificity of an anti-Bax antibody and potential data manipulation in cell migration and invasion assays. The journal lost confidence in the presented scientific data.

Area of Science:

  • Molecular Biology
  • Biochemistry
  • Immunology

Background:

  • A previously published study utilized an anti-Bax antibody (sc-7480) in molecular biology research.
  • Concerns were raised regarding the antibody's specificity, with evidence suggesting it binds to an unrelated protein.
  • Potential data duplication was identified in figures related to cell migration and invasion assays.

Purpose of the Study:

  • To address concerns about data integrity and antibody specificity in a published research paper.
  • To conduct an independent review of the presented experimental data.

Main Methods:

  • Review of published research data.
  • Assessment of antibody specificity using external study findings.
  • Analysis of figures for evidence of data manipulation or duplication.

Main Results:

  • The anti-Bax antibody (sc-7480) was found to be unspecific, binding to a protein of incorrect molecular weight (20-25 kDa).
  • Significant overlap was observed in data panels for cell migration and invasion assays, indicating potential duplication from fewer sources.
  • The journal's editorial office performed an independent review, confirming a lack of confidence in the presented data.

Conclusions:

  • The paper is retracted due to a lack of confidence in the presented data, stemming from issues with antibody specificity and data integrity.
  • The authors did not provide a satisfactory explanation to address the raised concerns.
  • The journal apologizes to readers for the inconvenience caused by the retracted publication.
Keywords:
apoptosisglioblastoma multiformeinvasionmicroRNA‑124‑3pmigrationproliferationsmall GTPase Ras homology Growth‑related

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