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Updated: Jan 31, 2026
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An Orthotopic Resectional Mouse Model of Pancreatic Cancer
Published on: September 24, 2020
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Relative Dose Intensity and Outcomes in Elderly Patients With Resectable Pancreatic Cancer Receiving Neoadjuvant
Tsuyoshi Takeda1, Masato Ozaka1, Takashi Sasaki1
1Department of Hepato-Biliary-Pancreatic Medicine, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.
Journal of Hepato-Biliary-Pancreatic Sciences
|January 30, 2026
Summary
Neoadjuvant chemotherapy (NAC) with gemcitabine and S-1 (GS) is feasible for elderly patients with resectable pancreatic cancer (PC). However, reduced dose intensity and increased AEs were observed in elderly patients and those with impaired renal function.
Area of Science:
- Oncology
- Gastroenterology
- Pharmacology
Background:
- Gemcitabine and S-1 (GS) neoadjuvant chemotherapy (NAC) is standard for resectable pancreatic cancer (PC) in Japan.
- Efficacy and safety of NAC GS in elderly patients and those with renal impairment are not well-established.
Purpose of the Study:
- To evaluate the efficacy and safety of NAC GS in elderly patients with resectable PC.
- To assess the impact of age and renal function on NAC GS outcomes.
Main Methods:
- Retrospective analysis of 185 patients with resectable PC who received NAC GS.
- Patients were categorized as elderly (≥75 years) or non-elderly (<75 years).
- Primary endpoint: relative dose intensity (RDI) of NAC; Secondary endpoints: adverse events (AEs), perioperative outcomes, adjuvant chemotherapy (AC) RDI, recurrence-free survival (RFS), and overall survival (OS).
Main Results:
- Elderly patients had significantly lower creatinine clearance (CCr) and mean RDI of GS.
- Lower RDI of GS was particularly noted in elderly patients with CCr <50 mL/min.
- Severe hematologic AEs were more frequent in elderly patients; however, perioperative outcomes, RFS, and OS did not significantly differ between age groups.
Conclusions:
- NAC GS is feasible in elderly patients with resectable PC.
- Caution is advised for elderly patients with impaired renal function due to potential dose reductions and increased AEs.
- Further research may be needed to optimize NAC GS regimens for specific patient subgroups.
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