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Updated: Jan 31, 2026

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Assessment of oxidative stress parameters in neonatal indirect hyperbilirubinemia treated with phototherapy

Emine Özçelik1, Salim Neşelioğlu2, Özcan Erel2

  • 1Department of Pediatrics, Dr. Sami Ulus Training and Research Hospital, University of Health Sciences, Ankara, Turkey.

Scandinavian Journal of Clinical and Laboratory Investigation
|January 30, 2026
PubMed

Insights

Indirect hyperbilirubinemia (IHB) and its common treatment, phototherapy, increase oxidative stress in newborns. This imbalance affects thiol-disulfide homeostasis and ischemia-modified albumin (IMA) levels, suggesting careful phototherapy use.

Area of Science:

  • Neonatal Medicine
  • Biochemistry
  • Oxidative Stress Research

Background:

  • Indirect hyperbilirubinemia (IHB) is a common neonatal condition.
  • Phototherapy is the standard treatment for IHB.
  • The impact of IHB and phototherapy on oxidative stress requires further investigation.

Purpose of the Study:

  • To assess the effect of IHB and phototherapy on oxidative stress markers.
  • To evaluate changes in thiol-disulfide homeostasis and ischemia-modified albumin (IMA).

Main Methods:

  • Prospective study of 107 newborns with IHB undergoing phototherapy and 55 controls.
  • Measurement of oxidative stress parameters, including thiol-disulfide homeostasis and IMA.
  • Comparison of parameters before and after phototherapy in the IHB group.

Main Results:

  • Newborns with IHB showed altered thiol-disulfide homeostasis compared to controls.
  • Phototherapy significantly reduced native thiol and total thiol levels.
  • Phototherapy increased disulfide levels, disulfide/thiol ratios, and IMA, indicating increased oxidative stress.

Conclusions:

  • Both IHB and phototherapy contribute to oxidative stress imbalance in newborns.
  • Thiol-disulfide homeostasis and IMA are sensitive indicators of this imbalance.
  • Phototherapy should be administered judiciously, for the shortest effective duration.

Keywords:
Oxidative stressdisulfidesinfantjaundicenewbornphototherapythiol groups

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