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A rostral prefrontal mediolateral gradient predicts creativity in frontotemporal dementia

Victor Altmayer1,2, Marcela Ovando-Tellez1, Théophile Bieth1,2

  • 1Sorbonne University, Institut du Cerveau - Paris Brain Institute - ICM, FrontLab, Inserm, CNRS, AP-HP, Hôpital de la Pitié Salpêtrière, 75013, Paris, France.

Brain : a Journal of Neurology
|January 30, 2026
PubMed
Summary

Creative thinking involves generating and combining ideas, supported by brain networks. The rostromedial PFC aids idea generation, while the rostrolateral PFC combines them, with both crucial for overall creativity.

Keywords:
associative thinkingconnectivity gradientscreativityfrontotemporal dementiaresting state functional connectivityvoxel-based morphometry

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