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Related Concept Videos

Endoscopic Procedures II: Colonoscopy01:25

Endoscopic Procedures II: Colonoscopy

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The colon, or large intestine, is the final segment of the digestive system. Its primary functions include absorbing water and vitamins produced by gut bacteria and transforming waste from liquid to solid to form stool. In adults, the large intestine is approximately 5 feet long and consists of four main sections:
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Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy01:26

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This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
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The rate of reaction is the change in the amount of a reactant or product per unit time. Reaction rates are therefore determined by measuring the time dependence of some property that can be related to reactant or product amounts. Rates of reactions that consume or produce gaseous substances, for example, are conveniently determined by measuring changes in volume or pressure.
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The equilibrium constant for a reaction is calculated from the equilibrium concentrations (or pressures) of its reactants and products. If these concentrations are known, the calculation simply involves their substitution into the Kc expression.
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The free energy change for a reaction that occurs under the standard conditions of 1 bar pressure and at 298 K is called the standard free energy change. Since free energy is a state function, its value depends only on the conditions of the initial and final states of the system. A convenient and common approach to the calculation of free energy changes for physical and chemical reactions is by use of widely available compilations of standard state thermodynamic data. One method involves the...
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Related Experiment Video

Updated: Jan 31, 2026

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
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Higher Sessile Serrated Lesion Detection Rates Calculated Using All Examinations Are Associated With Lower Risk for

Rachael Hagen1, Douglas K Rex2, Todd A MacKenzie3

  • 1Department of Medicine, University of Connecticut, Farmington, Connecticut, USA.

Clinical and Translational Gastroenterology
|January 30, 2026
PubMed
Summary

Higher sessile serrated lesion detection rates (SSLDR-A) in all colonoscopies are linked to a reduced risk of postcolonoscopy colorectal cancer (PCCRC). Endoscopists should aim for an SSLDR-A of 6%, with 8.0% or higher being aspirational.

Keywords:
adenomascolonoscopyserrated polypssurveillance

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Area of Science:

  • Gastroenterology
  • Oncology
  • Public Health

Background:

  • Sessile serrated lesion detection rate using all colonoscopy exams (SSLDR-A) may be a simpler quality metric than using only screening exams (SSLDR-S).
  • This metric could potentially predict postcolonoscopy colorectal cancer (PCCRC) risk.

Purpose of the Study:

  • To investigate the association between endoscopist-specific SSLDR-A and the risk of PCCRC.
  • To validate SSLDR-A as a quality metric for predicting PCCRC risk.

Main Methods:

  • A cohort of 115,585 patients from the New Hampshire Colonoscopy Registry (NHCR) with an index colonoscopy was analyzed.
  • Endoscopist-specific SSLDR-A and SSLDR-S were calculated and stratified into quintiles.
  • Cox regression models were used to assess the hazard of PCCRC, adjusting for covariates like patient age and sex.

Main Results:

  • Higher SSLDR-A and SSLDR-S rates were associated with lower PCCRC risks.
  • After covariate adjustment, higher SSLDR-A was linked to significantly lower PCCRC hazard ratios compared to the reference group (SSLDR-A <1.5%).
  • The highest quintiles of both SSLDR-A and SSLDR-S (8.0%+) demonstrated similar protection against PCCRC.

Conclusions:

  • Colonoscopies performed by endoscopists with higher SSLDR-A are associated with a reduced risk of PCCRC.
  • SSLDR-A is validated as a quality metric for predicting PCCRC risk.
  • An SSLDR-A of 6% is recommended, with 8.0% or higher considered aspirational.