Comparative Multi-Omics Analysis Identifies Shared Transcriptomic Signatures and Therapeutic Targets in Alzheimer's,...

Area of Science:

• Neuroscience
• Genomics
• Molecular Biology

Background:

• Alzheimer's (AD), Parkinson's (PD), and Huntington's (HD) are distinct neurodegenerative diseases with shared pathological features.
• Understanding molecular intersections between these disorders is crucial for developing effective treatments.

Purpose of the Study:

• To perform a comparative transcriptomic analysis of postmortem brain RNA-seq data from AD, PD, and HD patients.
• To identify shared and disease-specific transcriptional signatures and molecular pathways.

Main Methods:

• Utilized RNA-sequencing datasets from AD, PD, and HD.
• Identified differentially expressed genes (DEGs) and performed Gene Ontology (GO) enrichment analysis.
• Constructed protein-protein interaction (PPI) networks to identify central hub genes.

Main Results:

• Identified ten overlapping DEGs among AD, PD, and HD, with varying regulatory directions.
• Functional enrichment analysis revealed convergence on immune and inflammation-related biological processes.
• Key hub genes including MMP9, LCN2, CXCL2, CCL2, S100A8, and S100A9 were identified in the PPI network.

Conclusions:

• Neuroinflammatory signaling represents a shared molecular theme across Alzheimer's, Parkinson's, and Huntington's diseases.
• The identified hub genes and pathways offer potential therapeutic targets for these neurodegenerative disorders.
• Further validation in independent cohorts is warranted.