Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antigen Processing Pathways01:31

Antigen Processing Pathways

2.3K
MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
2.3K
Amyloid Fibrils03:03

Amyloid Fibrils

11.9K
Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
11.9K
Amyloid Fibrils03:03

Amyloid Fibrils

6.4K
6.4K
Mitochondrial Precursor Proteins01:39

Mitochondrial Precursor Proteins

3.8K
Mitochondrial precursors are partially unfolded or loosely folded polypeptide chains. Newly synthesized precursors are inhibited from spontaneously folding into their native conformation by the cytosolic chaperones, heat shock proteins 70 (Hsp70), and mitochondrial import stimulation factors (MSFs). Precursors bound to MSFs are guided to the TOM70-TOM37 receptors, while precursors bound to Hsp70  chaperones are targetted to TOM20-TOM22 receptor complexes.
Most of the mitochondrial...
3.8K
Review and Preview01:10

Review and Preview

8.4K
In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
8.4K
Review and Preview01:13

Review and Preview

11.2K
Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
11.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association between renin angiotensin system and cognitive outcomes over 15 years: The Look AHEAD study.

Journal of Alzheimer's disease : JAD·2026
Same author

A feasibility randomised controlled trial of water-only fasting prior to CAPOX chemotherapy for stage 2/3 colorectal cancer.

Pilot and feasibility studies·2026
Same author

Unravelling the effects of selective estrogen receptor modulators on colorectal cancer: a prognostic role for insulin-like growth factor binding protein-5.

Clinical science (London, England : 1979)·2026
Same author

Repurposing drugs for the prevention of vascular dementia using evidence from drug target Mendelian randomization.

Nature aging·2026
Same author

Towards optimal public health interventions for preventing obesity in children: a synopsis of a novel evidence synthesis.

Public health research (Southampton, England)·2026
Same author

Elevated Na<sup>+</sup>/K<sup>+</sup> Ratio in Alzheimer's Disease: A Potential Biomarker for Braak Stage.

International journal of molecular sciences·2026

Related Experiment Video

Updated: Jan 31, 2026

Purification and Aggregation of the Amyloid Precursor Protein Intracellular Domain
10:08

Purification and Aggregation of the Amyloid Precursor Protein Intracellular Domain

Published on: August 28, 2012

12.3K

Androgen Effects on Amyloid Precursor Protein Processing Pathways in Cancer: A Systematic Review.

Mai Alhadrami1, Gideon Stone2, Rachel M Barker1

  • 1Cancer Endocrinology Group, Learning & Research Building, Southmead Hospital, Translational Health Sciences, Bristol Medical School, Bristol BS10 5NB, UK.

Current Issues in Molecular Biology
|January 30, 2026
PubMed
Summary

Androgens, like dihydrotestosterone (DHT), increase amyloid precursor protein (APP) and ADAM10 in cancer cells, promoting proliferation. This suggests androgen signaling influences APP processing in cancer progression.

Keywords:
amyloid precursor protein and prostate cancerandrogens

More Related Videos

Rapid Generation of Amyloid from Native Proteins In vitro
05:48

Rapid Generation of Amyloid from Native Proteins In vitro

Published on: December 5, 2013

6.5K
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

13.9K

Related Experiment Videos

Last Updated: Jan 31, 2026

Purification and Aggregation of the Amyloid Precursor Protein Intracellular Domain
10:08

Purification and Aggregation of the Amyloid Precursor Protein Intracellular Domain

Published on: August 28, 2012

12.3K
Rapid Generation of Amyloid from Native Proteins In vitro
05:48

Rapid Generation of Amyloid from Native Proteins In vitro

Published on: December 5, 2013

6.5K
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

13.9K

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Androgens are implicated in cancer progression, particularly in hormone-dependent cancers.
  • Amyloid precursor protein (APP) plays a role in tumor growth and survival.
  • The link between androgens and APP processing in cancer remains under-explored.

Purpose of the Study:

  • To systematically review studies investigating the effects of androgens on APP and its cleavage enzymes in cancer.
  • To understand the role of androgen signaling in APP processing within cancer models.

Main Methods:

  • Systematic literature search of PubMed, Scopus, Web of Science, and EMBASE (2000-2024).
  • Inclusion of five experimental studies on prostate and breast cancer models.
  • Narrative synthesis of extracted data due to heterogeneity.

Main Results:

  • Dihydrotestosterone (DHT) or AR agonists increased ADAM10 expression and nuclear translocation in three studies.
  • APP was identified as an androgen-responsive gene, with androgens upregulating its expression in cancer cells.
  • Inhibition of APP or ADAM10 reduced cancer cell proliferation, confirming their role in tumor progression.

Conclusions:

  • Androgen signaling modulates APP processing in cancer, primarily via the non-amyloidogenic pathway.
  • Significant knowledge gaps exist regarding androgen-APP interactions in various cancer types.
  • Further research is needed to explore downstream signaling pathways and other cancer types.