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Genome-Wide Insights into Intermittent Milking Behavior of Pandharpuri Buffalo
Akshata Patil1, Parth Gaur1, Pritam Pal1
1Division of Animal Genetics and Breeding, ICAR-National Dairy Research Institute, Karnal 132001, Haryana, India.
Current Issues in Molecular Biology
|January 30, 2026
Summary
The Pandharpuri buffalo, unique for its intermittent milking, has its genomic architecture explored. Selection signatures reveal genes linked to milk production and lactation, offering insights for breeding strategies.
Area of Science:
- Genomics
- Animal Science
- Evolutionary Biology
Background:
- Buffaloes are vital to agriculture, providing milk, meat, and draft power.
- The Pandharpuri buffalo, an indigenous Indian breed, uniquely exhibits intermittent milking.
- Understanding its genome is crucial due to its evolutionary relevance and unique trait.
Purpose of the Study:
- To identify selection signatures in the Pandharpuri buffalo genome.
- To understand the genetic basis of intermittent milking.
- To explore evolutionary relationships and inform breeding strategies.
Main Methods:
- Whole-genome resequencing was performed on Pandharpuri buffalo.
- The De-Correlated Composite of Multiple Signals (DCMS) approach was used to detect selection signatures.
- Candidate genes associated with milk production and lactation were identified.
Main Results:
- 1337 candidate genes were identified, including those related to milk production.
- Genes such as ERBB4, ESR1, and SYK were highlighted for their potential role in intermittent milking.
- Genomic regions and biological pathways involved in lactation were revealed.
Conclusions:
- Genomic insights into Pandharpuri buffalo's intermittent milking capacity were gained.
- Identified genes and regions offer targets for improving lactation efficiency and resilience.
- This research supports genome-informed breeding for conserving unique buffalo germplasm.
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