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The Tumor Microenvironment02:17

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Related Experiment Video

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Microfluidic Device for Recreating a Tumor Microenvironment in Vitro
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Regulatory B Cells in Tumor Microenvironment.

Zhuoyan Cai1,2,3,4,5, Lin Xie1,2,3,4,5

  • 1Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Current Issues in Molecular Biology
|January 30, 2026
PubMed
Summary

Regulatory B cells (Bregs) are key players in the tumor microenvironment, suppressing immune responses. Targeting Bregs via epigenetic and metabolic pathways offers new therapeutic strategies for cancer treatment.

Keywords:
epigeneticsmetabolic remodelingregulatory B cellstumor immunitytumor immunotherapy

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Area of Science:

  • Immunology
  • Oncology
  • Cell Biology

Background:

  • Regulatory B cells (Bregs) are crucial immune cells within the tumor microenvironment (TME).
  • Bregs secrete immunosuppressive cytokines like IL-10, IL-35, and TGF-β, modulating anti-tumor immunity.
  • Their complex role in the TME necessitates a deeper understanding for therapeutic intervention.

Purpose of the Study:

  • To review recent findings on Breg phenotype and mechanisms in the TME.
  • To explore novel epigenetic and metabolic regulatory mechanisms influencing Bregs.
  • To investigate therapeutic strategies targeting Bregs for cancer immunotherapy.

Main Methods:

  • Literature review of recent studies on Bregs in the TME.
  • Analysis of epigenetic modifications (DNA methylation, histone acetylation) and metabolic pathways (glycolysis, oxidative phosphorylation) affecting Bregs.
  • Examination of therapeutic agents targeting Bregs, including STAT3 inhibitors.

Main Results:

  • Bregs exhibit a dual role in immune regulation within the TME.
  • Epigenetic and metabolic reprogramming significantly impacts Breg function.
  • STAT3 inhibitors like lipoxin A4 show potential in suppressing Breg activity.
  • Bregs contribute to tumorigenesis and metastasis, highlighting the need for immune pathway inhibition.

Conclusions:

  • Targeting Bregs, particularly through epigenetic and metabolic modulation, presents a promising avenue for cancer immunotherapy.
  • A comprehensive understanding of Breg function in the TME is essential for developing effective treatments.
  • Future strategies should focus on nuanced approaches to inhibit Breg-mediated immune suppression and prevent tumor escape.