Related Experiment Video

Updated: Jan 31, 2026

In Vivo Investigation of Antimicrobial Blue Light Therapy for Multidrug-resistant Acinetobacter baumannii Burn Infections Using Bioluminescence Imaging
09:29

In Vivo Investigation of Antimicrobial Blue Light Therapy for Multidrug-resistant Acinetobacter baumannii Burn Infections Using Bioluminescence Imaging

Published on: April 28, 2017

9.9K

Antimicrobial effect of biological surgical mesh added with vancomycin or silver nanoparticles for

Marcelo DE Paula Loureiro1,2, Pietro Maran Novais2, Ishmael Thomaz Padilha2

  • 1- Universidade Positivo, Pós-Graduação em Biotecnologia - Curitiba - PR - Brasil.

Revista Do Colegio Brasileiro De Cirurgioes
|January 30, 2026
PubMed
Abstract

Insights

Vancomycin-treated biological mesh effectively prevented surgical site infections in rats, outperforming polypropylene mesh and silver nanoparticle-coated mesh. Silver nanoparticles showed no antimicrobial benefit in this study.

Area of Science:

  • Biomaterials Science
  • Infectious Disease Research
  • Surgical Innovation

Background:

  • Surgical site infections (SSI) and polypropylene mesh (PPM) infections are significant challenges in abdominal hernia repair.
  • There is a critical need for novel antimicrobial materials to enhance surgical repair outcomes.

Purpose of the Study:

  • To evaluate the in vivo antimicrobial efficacy of a decellularized bovine pericardium (BP) biological mesh.
  • To assess BP mesh modified with vancomycin (VAN) or silver nanoparticles (AgNPs) for SSI prevention.

Main Methods:

  • Wistar rats underwent implantation of BP, PPM, BP-AgNPs, or BP-VAN meshes.
  • Meshes were inoculated with methicillin-resistant Staphylococcus aureus (MRSA).
  • Histological and bacteriological analyses were performed after 7 days.

Main Results:

  • BP-VAN demonstrated superior infection control compared to PPM and BP-AgNPs (p<0.0001).
  • BP-AgNPs showed reduced bacterial reduction versus BP C+ (p=0.042).
  • Histological analysis revealed mild inflammation with BP-VAN, moderate with BP C+, and intense with PPM and BP-AgNPs.

Conclusions:

  • Decellularized bovine pericardium with vancomycin exhibits significant antimicrobial properties for SSI prevention.
  • Silver nanoparticles did not confer antimicrobial efficacy in this experimental model.

More Related Videos

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro11:52

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Published on: April 21, 2023

3.9K
Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles05:50

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles

Published on: June 2, 2023

1.9K

Related Concept Videos

Mesh Analysis01:20

Mesh Analysis

Mesh analysis is a valuable method for simplifying circuit analysis using mesh currents as key circuit variables. Unlike nodal analysis, which focuses on determining unknown voltages, mesh analysis applies Kirchhoff's voltage law (KVL) to find unknown currents within a circuit. This method is particularly convenient in reducing the number of simultaneous equations that need to be solved.
A fundamental concept in mesh analysis is the definition of meshes and mesh currents. A mesh is a closed...
1.5K
Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
994
Mesh Analysis with Current Sources01:10

Mesh Analysis with Current Sources

Mesh analysis becomes simpler when analyzing circuits with current sources, whether independent or dependent. The presence of current sources reduces the number of equations required for analysis. Two cases illustrate this:
Current Source in One Mesh: The analysis process is straightforward when a current source is found in only one mesh within the circuit. Mesh currents are assigned as usual, with the mesh containing the current source excluded from the analysis. Kirchhoff's voltage law...
2.0K
Antimicrobial Proteins01:23

Antimicrobial Proteins

Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
14.3K
What is Conservation Biology?01:57

What is Conservation Biology?

Conservation biology is a scientific field that focuses on the preservation of biodiversity in order to protect ecosystems while meeting the needs of the human population. Humans require properly functioning ecosystems to maintain our supply of natural resources, including food, medicines, and building materials.
24.3K
Mesh Analysis for AC Circuits01:12

Mesh Analysis for AC Circuits

In the domain of radio communication, the significance of impedance matching must be considered. It is crucial to ensure the efficient transmission of signals between radio transmitters and receivers. Achieving this balance involves using impedance-matching circuits, with one fundamental configuration comprising a resistor, capacitor, and inductor.
The process of harmonizing these impedances begins with a clear understanding of the input and output signals. Once these signals are known, the...
702