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Updated: Jan 31, 2026
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Stereotactic heart ablative radiotherapy (SHARP): a prospective multicentric phase II trial
Aurélie Gaasch1, Sebastian N Marschner2,3, Philipp Hoegen-Saßmannshausen4
1Department of Radiation Oncology, LMU University Hospital, Munich, Germany. Aurelie.Gaasch@med.uni-muenchen.de.
Summary
Magnetic resonance-guided stereotactic body radiation therapy (MRgSBRT) shows promise for treating rare cardiac tumors. This study evaluates its feasibility, safety, and effectiveness in managing primary and secondary heart malignancies.
Area of Science:
- Oncology
- Radiotherapy
- Cardiovascular Medicine
Background:
- Cardiac tumors are rare, with metastases being the most common malignancy.
- Stereotactic body radiotherapy (SBRT) is an alternative treatment for inoperable cardiac tumors.
- Limited data exists on SBRT for cardiac malignancies.
Purpose of the Study:
- To evaluate the feasibility, toxicity, and outcomes of MRgSBRT for cardiac tumors.
- To assess the safety and effectiveness of online adaptive MRgSBRT.
- To establish a foundation for clinical guidelines.
Main Methods:
- Prospective, multicentric observational study (Phase II trial).
- MR-guided SBRT in five fractions (6-8 Gy per fraction).
- Four study centers involved; interdisciplinary tumor board approval.
Main Results:
- Primary objective: Assess feasibility and safety of online adaptive MRgSBRT.
- Secondary endpoints: Local control, survival, toxicity, patient-reported outcomes, technical feasibility.
- Data collection from four international centers.
Conclusions:
- MRgSBRT is a potential treatment for cardiac malignancies.
- Findings may inform future clinical practice guidelines.
- Further research is warranted to solidify its role.
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