Related Experiment Video
Updated: Jan 31, 2026
06:26
Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis
Published on: July 18, 2025
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Diastolic Dysfunction is Associated with Liver Fibrosis and Insulin Resistance in Alcohol Use Disorder
Anna Hernández-Rubio1,2, Sara Ceballos1,2, Xavier García-Calvo2,3
1Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.
Journal of General Internal Medicine
|January 30, 2026
Summary
Diastolic dysfunction is common in individuals with alcohol use disorder (AUD), even without symptoms. This cardiac issue is linked to advanced liver fibrosis and insulin resistance in AUD patients.
Area of Science:
- Cardiology
- Hepatology
- Endocrinology
Background:
- Alcohol use disorder (AUD) is linked to significant health issues like cardiomyopathy, liver disease, and metabolic disturbances.
- Early detection of cardiac abnormalities in AUD patients is crucial for timely intervention.
Purpose of the Study:
- To investigate echocardiographic abnormalities in asymptomatic AUD patients undergoing inpatient treatment.
- To determine the association between these abnormalities, advanced liver fibrosis, and insulin resistance.
Main Methods:
- A cross-sectional study involving 145 AUD patients admitted for inpatient treatment.
- Echocardiography, FIB-4 index for liver fibrosis, and triglyceride/HDL ratio for insulin resistance were assessed.
- Multivariate logistic regression analyzed associations between cardiac findings, liver fibrosis, and insulin resistance.
Main Results:
- Diastolic dysfunction was prevalent in 66% of patients; systolic impairment was rare (5%).
- Advanced liver fibrosis (FIB-4 > 3.25) was more common in patients with diastolic dysfunction (p=0.010).
- Diastolic dysfunction was independently associated with advanced liver fibrosis (OR 3.53) and insulin resistance (OR 4.55).
Conclusions:
- Diastolic dysfunction is a frequent echocardiographic finding in asymptomatic AUD patients.
- Advanced liver fibrosis and insulin resistance are independently associated with diastolic dysfunction in this population.
- These findings highlight the importance of cardiac screening in AUD management.
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