Related Experiment Video

Updated: Jan 31, 2026

Nerve Stem Cell Differentiation by a One-step Cold Atmospheric Plasma Treatment In Vitro
07:01

Nerve Stem Cell Differentiation by a One-step Cold Atmospheric Plasma Treatment In Vitro

Published on: January 11, 2019

7.9K

Recent advances in the pathophysiology and treatment of plasma cell dyscrasias

Kazuhito Suzuki1

  • 1Division of Clinical Oncology/Hematology, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-Ku, Tokyo, 105-0003, Japan. kaz-suzuki@jikei.ac.jp.

International Journal of Hematology
|January 30, 2026
PubMed

Insights

Multiple myeloma prognosis has improved with new therapies, especially for triple-class-exposed (TCE) patients. Functional cure, involving long-term disease control and suppressed minimal residual disease (MRD), is now a realistic goal.

Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • Multiple myeloma is an incurable plasma cell cancer.
  • Previous treatments improved outcomes but not for triple-class-exposed (TCE) patients.

Purpose of the Study:

  • To review advancements in multiple myeloma treatment.
  • To highlight improved outcomes in TCE myeloma with novel therapies.
  • To define functional cure as a therapeutic goal.

Main Methods:

  • Literature review of recent clinical trials and therapeutic advancements.
  • Analysis of treatment outcomes in triple-class-exposed multiple myeloma.
  • Definition and exploration of functional cure in multiple myeloma.

Main Results:

  • CAR-T cell therapy and bispecific antibodies significantly improved prognosis in TCE myeloma.
  • Functional cure, characterized by sustained MRD suppression, is achievable.
  • A favorable immune microenvironment is key for long-term disease control.

Conclusions:

  • Novel therapies offer new hope for previously refractory multiple myeloma.
  • Functional cure represents a shift towards long-term management rather than complete eradication.
  • Continued research into immune modulation is crucial for achieving functional cure.
Keywords:
B-cell maturation antigenMicroenvironmentMinimal residual diseaseMultiple myelomaSmoldering myeloma

More Related Videos

Basic Research in Plasma Medicine - A Throughput Approach from Liquids to Cells07:37

Basic Research in Plasma Medicine - A Throughput Approach from Liquids to Cells

Published on: November 17, 2017

13.4K
Investigating the Detrimental Effects of Low Pressure Plasma Sterilization on the Survival of Bacillus subtilis Spores Using Live Cell Microscopy10:03

Investigating the Detrimental Effects of Low Pressure Plasma Sterilization on the Survival of Bacillus subtilis Spores Using Live Cell Microscopy

Published on: November 30, 2017

10.0K

Related Concept Videos

Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:
2.9K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.6K
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
937
Pathophysiology of Vomiting01:22

Pathophysiology of Vomiting

Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through...
3.0K
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
1.3K
Protein Buffers in Blood Plasma and Cells01:20

Protein Buffers in Blood Plasma and Cells

The human body utilizes protein buffer systems to maintain a stable pH. These systems capitalize on the dual role of amino acids, which can act as acids or bases by accepting or releasing hydrogen ions in response to pH changes. Protein buffer systems are particularly significant in the extracellular fluid (ECF) and intracellular fluid (ICF) of active cells, where structural and functional proteins provide substantial buffering capacity.
Certain amino acids can exist in a zwitterion state at a...
3.8K