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Updated: Jan 31, 2026

Peptide Scanning-assisted Identification of a Monoclonal Antibody-recognized Linear B-cell Epitope
Published on: March 24, 2017
Epitope Recognized by anti-A,B Antibodies of Blood Group O Individuals as Probed with STD NMR
S V Tsygankova1, P S Obukhova2,3, T V Tyrtysh2
1M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia. svlush@mail.ru.
Abstract:
The serum of people with blood group O contains not only classical anti-A and anti-B, but also anti-A,B antibodies, i.e., those whose Fab region equally recognizes both the A and B blood group antigens. The common epitope of the A and B antigens, recognized by these antibodies, is located strictly on one side of the tetrasaccharide molecule, which was shown by studying their complex with anti-A,B antibodies using the Saturation Transfer Difference (STD NMR) spectroscopy.
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