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Related Experiment Video

Updated: Jan 31, 2026

Orthotopic Mouse Model of Colorectal Cancer
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Colorectal Cancer Screening Among People With Intellectual Disabilities.

Trine Allerslev Horsbøl1, Susan Ishøy Michelsen1, Trine Toft Sørensen1

  • 1National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.

JAMA Network Open
|January 30, 2026
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Summary
This summary is machine-generated.

People with intellectual disabilities (ID) show lower colorectal cancer screening participation and completion rates. Tailored strategies are needed to address these disparities and improve equitable access to cancer screening for individuals with ID.

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Area of Science:

  • Public Health
  • Cancer Screening
  • Health Disparities

Background:

  • Colorectal cancer (CRC) mortality is higher in individuals with intellectual disabilities (ID), potentially due to delayed diagnosis.
  • Effective CRC screening is crucial for early detection and improved outcomes.

Purpose of the Study:

  • To compare CRC screening participation and completion rates between individuals with and without ID.
  • To identify potential barriers and disparities in the screening process for people with ID.

Main Methods:

  • Nationwide, register-based cohort study in Denmark (2014-2023).
  • Inclusion of residents aged 50-74 years invited to biennial CRC screening.
  • Comparison of screening participation (stool sample return) and completion (diagnostic examination) between individuals with and without ID, adjusting for disability severity.

Main Results:

  • Individuals with ID had significantly lower participation in CRC screening (30.2% vs 56.1%) and diagnostic examination completion (70.5% vs 90.2%) compared to those without ID.
  • Participation and completion rates decreased with increasing severity of intellectual disability.
  • Challenges with stool sample collection and colonoscopy completion were more common among individuals with ID.

Conclusions:

  • Individuals with intellectual disabilities face significant barriers in participating in and completing colorectal cancer screening.
  • Disparities in screening participation and completion highlight the need for tailored, decision-supportive strategies to ensure equitable cancer care.
  • Addressing these disparities is essential for reducing colorectal cancer mortality in the ID population.