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Related Experiment Video

Updated: Feb 1, 2026

Activating Autophagy by Aerobic Exercise in Mice
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PLETHORA-autophagy axis activates organ regeneration through ROS modulation.

Akansha Ganguly1, Aabha Humnabadkar1, Komal Gautam1

  • 1Department of Biology, Indian Institute of Science Education and Research, Pune 411008, India.

Proceedings of the National Academy of Sciences of the United States of America
|January 30, 2026
PubMed
Summary
This summary is machine-generated.

Plants use autophagy, a cellular recycling process, to manage stress and regenerate roots after injury. This pathway, regulated by PLETHORA transcription factors, is crucial for root regeneration but not callus formation.

Keywords:
PLETHORAROSautophagyde novo root regenerationstem cell

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Area of Science:

  • Plant biology
  • Cellular stress response
  • Molecular mechanisms of regeneration

Background:

  • Cellular homeostasis is disrupted by injury, leading to stress at wound sites.
  • Autophagy is a conserved pathway for recycling cellular components to maintain homeostasis.

Purpose of the Study:

  • To investigate the role of autophagy in plant wound repair and regeneration.
  • To understand how plants manage wound-induced cellular stress.

Main Methods:

  • Examined transcriptional activation of autophagy-related gene 8 (ATG8) genes.
  • Investigated the function of PLETHORA (PLT) transcription factors in regulating ATG8.
  • Assessed the impact of disrupting the PLT-ATG8 axis on organelle turnover and reactive oxygen species (ROS) levels.

Main Results:

  • Transcriptional activation of ATG8 genes is essential for de novo root regeneration but not callus formation.
  • PLT transcription factors activate a subset of ATG8 genes and are critical for this process.
  • Disruption of the PLT-ATG8 axis impairs organelle turnover, increases intracellular stress, and leads to ectopic ROS accumulation.

Conclusions:

  • The PLT-ATG8 regulatory axis manages wound-induced cellular stress by optimizing ROS levels.
  • This pathway promotes stem cell regulator expression, facilitating de novo root regeneration.
  • Plants use specific developmental regulators like PLTs to activate conserved pathways for stress management and regeneration.