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Biofunctionalization of Magnetic Nanomaterials
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Morphology-Driven 99mTc Extraction from Molybdenum Disulfide Nanomaterials
Gauri1, Antonia G Denkova1, Robin M de Kruijff1
1Department of Radiation Science and Technology, Delft University of Technology, Delft 2629 JB, The Netherlands.
ACS Applied Materials & Interfaces
|January 30, 2026
Summary
Researchers developed novel molybdenum disulfide (MoS2) nanomaterials for improved technetium-99m (99mTc) production. These recyclable nanomaterials offer a cost-effective and efficient alternative for nuclear medicine diagnostics.
Area of Science:
- Nuclear medicine and radiochemistry
- Materials science and nanotechnology
Background:
- Technetium-99m (99mTc) is crucial for nuclear medicine diagnostics.
- Current production relies on uranium fission, generating nuclear waste and facing reactor limitations.
- Alternative methods yield low-specific-activity 99mTc, incompatible with conventional generators.
Purpose of the Study:
- To develop a novel, recyclable 99mTc generator system.
- To utilize molybdenum-based nanomaterials as both target and generator material.
- To overcome limitations of low-specific-activity 99mTc production.
Main Methods:
- Synthesis of molybdenum disulfide (MoS2) nanomaterials with diverse morphologies (nanoflowers, nanotubes, nanodispersed sheets).
- Evaluation of nanomaterial properties and their impact on 99mTc extraction efficiency.
- Testing of nanodispersed sheets for extraction performance and recyclability.
Main Results:
- Nanomaterial morphology significantly affects 99mTc extraction.
- MoS2 nanodispersed sheets, with high surface area, achieved 12% 99mTc extraction in MEK.
- Negligible molybdenum contamination and excellent structural stability over multiple cycles were observed.
Conclusions:
- Molybdenum-based nanomaterials offer a promising alternative for 99mTc generation.
- The developed nanodispersed sheets enable efficient and recyclable 99mTc extraction.
- This approach paves the way for cost-effective and sustainable nuclear medicine.
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