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Updated: Feb 1, 2026

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
Published on: June 1, 2012
Light-Addressable Photoelectrochemical Sensors for High-Throughput and Multiplex Detection: Principles, Applications,
Yukun Yang1, Fuguo Ge1, Xiangyu Yao1
1School of Life Science, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, China.
Abstract:
Light-addressable photoelectrochemical sensors (LAPECS) have gained increasing attention as a promising platform for multiplexed detection owing to their integration of photo-addressing and photoelectrochemical techniques. By using programmable illumination to confine photoinduced electron transfer to specific electrode regions, this straightforward strategy enables high-throughput and multiplexed detection and has shown promise in biomedical diagnostics, environmental monitoring, and food safety analysis. In this review, we provide a comprehensive overview of the fundamental principles and the structural and functional components of LAPECS. This review also summarizes three representative operational modes: multi-electrode parallel, single-electrode multi-channel partitioning, and microarray chip-based modes. We further discuss emerging solutions, including advanced recognition interfaces, miniaturized designs, and machine learning-assisted data processing, to address current challenges in LAPECS, such as limited specificity, signal interference, and integration complexity. Finally, the current research challenges and future prospects of LAPECS are discussed.
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