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Updated: Feb 1, 2026

Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization
Published on: September 2, 2022
Corosolic acid as a dual-function stabilizer in W/O Pickering emulsions enhances its bioaccessibility and
Baozhu Shi1, Yueran Ma2, Dong Li3
1College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China; ZhongYuan Institute, Zhejiang University, Zhengzhou 450001, China.
Abstract:
Corosolic acid (CA) is a potent α-glucosidase inhibitor, but its application is limited by poor aqueous solubility and low bioaccessibility. In this study, a CA-stabilized water-in-oil (W/O) Pickering emulsion was proposed as a self-assembled delivery strategy to overcome these limitations. The emulsion markedly improved the gastrointestinal performance of CA, leading to a substantially higher bioaccessibility (28.54%) compared with crystalline CA (6.48%). Enzyme kinetic analysis for CA emulsion showed an apparent non-competitive inhibition mode and enhanced α-glucosidase inhibition with a reduced Ki and IC50. Molecular dynamics simulations supported stable binding interactions consistent with an allosteric inhibition mechanism. Overall, this work demonstrates that structuring CA into a W/O Pickering emulsion can simultaneously improve its bioaccessibility and inhibitory efficiency, providing a conceptual framework for enhancing the functionality of poorly soluble triterpenoids.
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