Controllable construction and corrosion control of MOFs membranes based multifunctional coatings on medical magnesium...

Biodegradable magnesium (Mg) and its alloys can degrade safely in vivo without toxicity to the human body. However, the major bottleneck inhibiting Mg-based implants' clinical use is the high corrosion rate. The serious corrosion leads to loss of mechanical integrity prematurely and bad biocompatibility. To break the bottleneck, modification with anticorrosive and bioactive coating is an ideal strategy. Metal-organic frameworks (MOFs) show good anticorrosive performance and perform good biocompatibility with up-and-coming applications in biomedical area such as drug delivery system, biological imaging and antibacterial property. Although numerous reports have reviewed the preparation and application of magnesium-based implant coating, relatively few report the MOF membranes coating of magnesium-based implant. Herein, this review provides the strategies for controlling corrosion of magnesium-based implants. Meanwhile, fabrication of nanoscale MOF membranes (in-situ growth and secondary growth method) is also mentioned. The application of MOFs based materials in the fields of corrosion protection and biomedicine are introduced. This work aims to provide a theoretical basis for addressing the key challenges of corrosion protection and biofunctionalization of degradable metal implants by systematically analyzing the functional characteristics and engineering design principles of MOFs coatings on magnesium-based implants.