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Single-cell aging clocks: A precision tool for dissecting and targeting the aging process.
Yuduo Hao1, Sijia Xie1, Yijie Wei1
1Department of Clinical Laboratory, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China.
Ageing Research Reviews
|January 30, 2026
Summary
Single-cell aging clocks reveal aging's complexity, showing it's a malleable process. These advanced tools enable precision interventions to extend human healthspan.
Area of Science:
- Gerontology
- Molecular Biology
- Computational Biology
Background:
- Biological age is a key health indicator, traditionally measured by bulk tissue aging clocks.
- Bulk clocks average cellular signals, masking crucial cellular heterogeneity in aging.
- Single-cell technologies offer higher resolution to overcome these limitations.
Purpose of the Study:
- To systematically review single-cell aging clocks.
- To cover their computational basis and biological insights.
- To highlight their impact on understanding aging.
Main Methods:
- Review of recent literature on single-cell aging clocks.
- Analysis of computational methodologies underpinning these clocks.
- Synthesis of biological insights derived from single-cell aging data.
Main Results:
- Single-cell clocks quantify "mosaic aging" and reveal aging's plasticity.
- They track cell-type-specific age acceleration and reversal.
- New frontiers include "age reset" in embryogenesis and longevity research.
Conclusions:
- Aging is a regulated, potentially malleable biological program, not just passive decline.
- Single-cell aging clocks are foundational for precision health interventions.
- These tools are crucial for extending human healthspan.
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